Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease

Li, Meng-Ting; Lin, Shuangzhe; Cheng, Yuqing; Fan, Jian‐Gao; Chen, Yuan-Wen

doi:10.14218/jcth.2022.00110

Cited by 1 publication

(1 citation statement)

References 50 publications

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“…The latest data suggest that its occurrence is on the rise worldwide, reaching 24% and resulting in a substantial financial burden. 146 A study found that human umbilical cord MSC-EVs containing miR-627-5p could improve insulin tolerance, alleviate liver injury, modulate glucose/lipid metabolism and reduce lipid deposition in an MAFLD rat model. 136 The effects were associated with miR-627-5p targeting and suppressing Fat Mass and Obesity associated (FTO) gene expression.…”

Section: Msc-evs and Metabolism-associated Fatty Liver Disease (Mafld)mentioning

confidence: 99%

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

Zhu,

Wang,

Guo

et al. 2024

JIR

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Chronic liver conditions are associated with high mortality rates and have a large adverse effect on human well-being as well as a significant financial burden. Currently, the only effective treatment available for the effects of liver failure and cirrhosis resulting from the progression of several chronic liver diseases is liver transplantation carried out at the original location. This implies that developing novel and effective treatments is imperative. Regenerative medicine has long been associated with stem cell therapy. Mesenchymal stem cells (MSCs), a type of cell with great differentiation potential, have become the preferred source for stem cell therapy. According to recent studies, MSCs’ paracrine products—rather than their capacity for differentiation—play a significant therapeutic effect. MSC exosomes, a type of extracellular vesicle (MSC-EV), came into view as the paracrine substances of MSCs. According to research, MSC exosomes can maintain tissue homeostasis, which is necessary for healthy tissue function. All tissues contain them, and they take part in a variety of biological activities that support cellular activity and tissue regeneration in order to preserve tissue homeostasis. The outcomes support the use of MSCs and the exosomes they produce as a therapeutic option for a range of diseases. This review provides a brief overview of the source of MSC-EVs and outlines their physiological roles and biochemical capabilities. The elucidation of the role of MSC-EVs in the recovery and repair of hepatic tissues, as well as their contribution to maintaining tissue homeostasis, is discussed in relation to different chronic liver diseases. This review aims to provide new insights into the unique roles that MSC-EVs play in the treatment of chronic liver diseases.

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Section: Msc-evs and Metabolism-associated Fatty Liver Disease (Mafld)mentioning

confidence: 99%

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

Zhu,

Wang,

Guo

et al. 2024

JIR

View full text Add to dashboard Cite

show abstract

Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease

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Cited by 1 publication

References 50 publications

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?

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