Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats

Sani, Maryam Arabloei; Yaghmaei, Parichehreh; Hajebrahimi, Zahra; Roodbari, Nasim Hayati

doi:10.1155/2022/1015669

Cited by 14 publications

(12 citation statements)

References 47 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The natural product p -cymene ( 97 , Figure 4 ) is an aromatic, cyclic monoterpene that has been demonstrated to have antioxidant properties in vivo. A study conducted in diabetes induced Wistar rats demonstrated this compound’s ability to upregulate mTOR, AKT, and phospho-AKT enzymes all of which being crucial regulators of oxidative stress [ 56 ]. The diabetes induced rats were dosed with either 55 mg/kg of metformin, an approved type II diabetes medication, or 25, 50, 100 mg/kg of p -cymene.…”

Section: Biological Activities Of Monoterpenesmentioning

confidence: 99%

“…The diabetes induced rats were dosed with either 55 mg/kg of metformin, an approved type II diabetes medication, or 25, 50, 100 mg/kg of p -cymene. All groups were successful in increasing the expression of these key oxidative stress regulatory enzymes [ 56 ]. It is worth noting that although the 25, and 50 mg/kg groups were less effective than metformin, the 100 mg/kg group was able to upregulate these enzymes to a comparable degree as the metformin group [ 56 ].…”

Section: Biological Activities Of Monoterpenesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product

Barras,

Ling,

Rivas

2024

Molecules

View full text Add to dashboard Cite

Monoterpenes and meroterpenes are two large classes of isoprene-based molecules produced by terrestrial plants and unicellular organisms as diverse secondary metabolites. The global rising incidence of cancer has led to a renewed interest in natural products. These monoterpenes and meroterpenes represent a novel source of molecular scaffolds that can serve as medicinal chemistry platforms for the development of potential preclinical leads. Furthermore, some of these natural products are either abundant, or their synthetic strategies are scalable as it will be indicated here, facilitating their derivatization to expand their scope in drug discovery. This review is a collection of representative updates (from 2016–2023) in biologically active monoterpene and meroterpenoid natural products and focuses on the recent findings of the pharmacological potential of these bioactive compounds as well as the newly developed synthetic strategies employed to access them. Particular emphasis will be placed on the anticancer and antioxidant potential of these compounds in order to raise knowledge for further investigations into the development of potential anti-cancer therapeutics. The mounting experimental evidence from various research groups across the globe regarding the use of these natural products at pre-clinical levels, renders them a fast-track research area worth of attention.

show abstract

Section: Biological Activities Of Monoterpenesmentioning

confidence: 99%

Section: Biological Activities Of Monoterpenesmentioning

confidence: 99%

Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product

Barras,

Ling,

Rivas

2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Improves HbA1c and nephropathic parameters (such as albumin excretion rate, serum creatinine, and creatinine clearance rate). [33] p-Cymene STZ-induced diabetic rats-25, 50, and 100 mg/kg Improve serum levels of Glu, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and the expression of mTOR, Akt, and phospho-Akt protein [69] Eucalyptol Diabetic db/db mice-10 mg/kg It increased the expression of nephrin, podocin, FAT-1, CD2AP, α-actinin-4, and integrin. Blocked ERK-c-Myc signaling.…”

Section: Catalpolmentioning

confidence: 99%

“…p-Cymene administration improved the amount of malondialdehyde (MDA) in diabetic rats (p ≤ 0.001). Administration of pcymene (100 mg/kg) can improve islet of Langerhans changes in diabetic rats and increase the expression of Akt, phospho-Akt, and mTOR, reducing liver and pancreatic injury [69].…”

Section: Catalpolmentioning

confidence: 99%

Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review

Sousa,

Viana,

Coêlho

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent years. Due to nature’s complex biosynthetic machinery, they also exhibit a reasonable degree of structural complexity/diversity for further analysis in structure-activity studies. Therefore, monoterpenes as antidiabetic agents have been investigated by recent in vitro and in vivo studies extensively reported in the scientific literature and claimed by patent documents. The purpose of this survey is to provide a comprehensive and prospective review concerning the potential applications of monoterpenes in the treatment of diabetes. The data for this research were collected through the specialized databases PubMed, Scopus, Web of Science, and ScienceDirect between the years 2014 and 2022, as well as the patent databases EPO, WIPO, and USPTO. The research used 76 articles published in the leading journals in the field. The main effect observed was the antidiabetic activity of monoterpenes. This review showed that monoterpenes can be considered promising agents for prevention and/or treatment of diabetes as well as have a marked pharmaceutical potential for the development of bioproducts for therapeutics applications.

show abstract

“…Prolonged hyperglycemia connected with several chronic metabolic problems is referred to as DM complications. Elevated blood glucose levels in type 2 diabetes (T2D) patients can cause serious, even catastrophic, vascular consequences such as amputations, atherosclerosis, retinopathy, neuropathy, and nephropathy [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

El Azab,

Alakilli,

Saleh

et al. 2023

IJMS

View full text Add to dashboard Cite

Type 2 diabetes (T2D) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. The utilization of phytochemical therapy generated from plants has emerged as a promising approach for the treatment of diabetes and its complications. Kiwifruit is recognized for its substantial content of antioxidative phenolics. Therefore, this work aimed to examine the effect of Actinidia deliciosa (kiwi fruit) on hepatorenal damage in a high-fat diet (HFD) and streptozotocin (STZ)-induced T2D in rats using in vivo and in silico analyses. An increase in hepatic and renal lipid peroxidation was observed in diabetic rats accompanied by a decrease in antioxidant status. Furthermore, it is important to highlight that there were observable inflammatory and apoptotic responses in the hepatic and renal organs of rats with diabetes, along with a dysregulation of the phosphorylation levels of mammalian target of rapamycin (mTOR), protein kinase B (Akt), and phosphoinositide 3-kinase (PI3K) signaling proteins. However, the administration of kiwi extract to diabetic rats alleviated hepatorenal dysfunction, inflammatory processes, oxidative injury, and apoptotic events with activation of the insulin signaling pathway. Furthermore, molecular docking and dynamic simulation studies revealed quercetin, chlorogenic acid, and melezitose as components of kiwi extract that docked well with potential as effective natural products for activating the silent information regulator 1(SIRT-1) pathway. Furthermore, phenolic acids in kiwi extract, especially syringic acid, P-coumaric acid, caffeic acid, and ferulic acid, have the ability to inhibit the phosphatase and tensin homolog (PTEN) active site. In conclusion, it can be argued that kiwi extract may present a potentially beneficial adjunctive therapy approach for the treatment of diabetic hepatorenal complications.

show abstract

Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats

Cited by 14 publications

References 47 publications

Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product

Recent Advances in Chemistry and Antioxidant/Anticancer Biology of Monoterpene and Meroterpenoid Natural Product

Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

Contact Info

Product

Resources

About