Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis

Silva, S.A.G. Da; Costa, Sônia Soares; Mendonça, Sergio C. F.; Silva, E.M.; Moraes, Vera Lúcia Gonçalves de; Rossi-Bergmann, Bartira

doi:10.1016/0001-706x(95)00128-2

Cited by 74 publications

(57 citation statements)

References 15 publications

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“…The oral treatment was most effective and was able to prevent or delay the onset of lesions in a sustained manner. Additionally, after oral, i. p., or topical application, titers of a parasite-specific antibody (IgG) were reduced to 20 % when compared with untreated mice [84]. Interestingly, the activity was abolished in vitro and in vivo by cotreatment with N-monomethylarginine, an inhibitor of inducible NO synthase and, hence, of NO production.…”

Section: Antileishmanial Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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Section: Antileishmanial Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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“…Antiparasitic (anti-leishmania), antibacterial, hepatoprotective and immunomodulatory activities have been described for Kp leaf extracts (Da Silva et al 1995;Akinpelu, 2000;Muñoz et al 2000;Yadav and Dixit, 2003;Rossi-Bergmann et al 1994;Almeida et al, 2000). Exploratory toxicological studies in mice and humans have indicated absence of chronic and acute oral toxicity (Torres-Santos et al, 2003, Sousa et al, 2005.…”

Section: Fig 2 Kalanchoe Pinnata (Crassulaceae) : Leaves and Inflormentioning

confidence: 99%

“…Despite the early reports on the antihistaminic activity of Kp using the experimental models of isolated guinea pig ileum contraction and vasodilatation in rats (Nassis et al, 1992); its fatty acid associated suppressive activity on T cells (Rossi-Bergmann et al, 1994, Almeida et al, 2000. ), and its Th2-suppressive and iNOSsuppressive association with oral protection against cutaneous and visceral leishmaniasis (Da-Silva et al, 1995, Da-Silva et al, 1999, Gomes et al 2009), only recently the therapeutic effect of Kp in allergy was more deeply explored. The antianaphylactic activity o Kp was studied using a murine model of OVA-induced anaphylactic shock.…”

Section: The Anti-anaphylactic Effect Of the Aqueous Extract Of Kalanmentioning

confidence: 99%

Preventive Phytotherapy of Anaphylaxis and Allergic Reactions[MSOffice1]

Cruz¹,

Muzitano²,

Costa³

et al. 2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…Oral treatment with leaf extract significantly delayed onset of disease in BALB/c mice infected with Leishmania amazonensis as compared to untreated mice or mice receiving K. pinnata by the intravenous or topical routes 6 . Potent cytotoxic compounds bersaldegenin-1, 3, 5-orthoacetate 7 and bufadienolide-bryophyllin B 8 were isolated.…”

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confidence: 91%

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2011

IJPSR

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The plant Kalanchoe pinnata is widely used in ayurvedic system of medicine as astringent, analgesic, carminative and also useful in diarrhea and vomiting. Naturalized throughout the hot and moist parts of India. And lots of phytochemical and pharmacological work has done on leaves of plant but the root part is not focused. Hence we have selected roots for phytochemical analysis which will support further evaluation of pharmacological activity. In this first roots are subjected to chloroform for extraction. And preliminary phytochemical test were performed. Chloroform extract was subjected for HPLC and GC-MS analysis which shows various phytoconstituents present in extract.

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Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis

Cited by 74 publications

References 15 publications

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Preventive Phytotherapy of Anaphylaxis and Allergic Reactions[MSOffice1]

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