Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury

Eroğlu, Nilgün; Erduran, Erol; Reis, Gökçe Pınar; Bahadır, Ayşenur

doi:10.1007/s11845-020-02219-1

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Many publications report that increased levels of this factor in cells promote the initiation and progression of cancer [53,54]. On the other hand, increased levels of GSH may be a response to the toxic effects of the tested factor [55,56]. In the present study, GSH levels increased significantly in group M (by approximately 30%), GN (by approximately 130%), and GO (by approximately 100%), while a decrease relative to the control was seen in the MGN group (by approximately 15%) (Figure 2C).…”

Section: Discussionmentioning

confidence: 99%

Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane

Daniluk

Lange

Wójcik

et al. 2023

IJMS

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One of the components of bee venom is melittin (M), which has strong lysing properties on membranes. M has high toxicity to cancer cells, but it also affects healthy cells, making it necessary to use methods for targeted delivery to ensure treatment. This research is a continuation of previous studies using graphene nanomaterials as M carriers to breast cancer cells. The studies described below are conducted on a more organized biological structure than what is found in vitro cells, namely, cancerous tumors grown on a chicken embryo chorioallantoic membrane. Caspase 3 and 8 levels are analyzed, and the level of oxidative stress markers and changes in protein expression for cytokines are examined. The results show that M complexes with nanomaterials reduce the level of oxidative stress more than M alone does, but the use of graphene (GN) as a carrier increases the level of DNA damage to a greater extent than the increase caused by M alone. An analysis of cytokine levels shows that the use of the M and GN complex increases the level of proteins responsible for inhibiting tumor progression to a greater extent than the increase occasioned by a complex with graphene oxide (GO). The results suggest that the use of GN as an M carrier may increase the toxic effect of M on structures located inside a cell.

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Section: Discussionmentioning

confidence: 99%

Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane

Daniluk

Lange

Wójcik

et al. 2023

IJMS

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“…N‐acetylcysteine is a precursor to glutathione, which counteracts the harmful effect of reactive oxygen and nitrogen species through both direct and indirect scavenging 34 . It is widely used in the treatment of paracetamol overdose and has been shown in human medicine to have a therapeutic effect on hepatotoxicity caused by chemotherapy agents 35 . This treatment was given over 3 days during initial management of the lomustine overdose.…”

Section: Discussionmentioning

confidence: 99%

“…34 It is widely used in the treatment of paracetamol overdose and has been shown in human medicine to have a therapeutic effect on hepatotoxicity caused by chemotherapy agents. 35 This treatment was given over 3 days during initial management of the lomustine overdose. Marked elevation in the liver values was noted only 3 weeks later, and it is difficult to assess the effect of N-acetylcysteine, and whether it could have delayed or lessened the hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Use of eltrombopag and granulocyte colony‐stimulating factor in treatment of lomustine overdose in a dog

Aspinall

Desmas²,

Bazelle³

2021

Vet Record Case Reports

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An 8‐year‐old male neutered golden retriever diagnosed with a T‐cell lymphoma and treated with a modified LOPP (lomustine, vincristine, prednisolone and procarbazine) protocol was presented to a referral hospital for management of an accidental overdose of lomustine (180 mg/m2). This overdose resulted in a severe myelosuppression with neutropenia and thrombocytopenia. The human platelet stimulator eltrombopag was used as part of the treatment protocol, alongside granulocyte‐macrophage colony‐stimulating factor and supportive care. The dog made a good recovery and completed a course of chemotherapy, achieving complete clinical remission of the lymphoma and long‐term survival (613 days).

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“…• внутривенный 21часовой режим: насыщающая (ударная) доза в виде инфузии 150 мг / кг в течение 1 ч, далее 50 мг / кг в течение 4 ч, затем 100 мг / кг в течение 16 ч. В недавней работе была оценена эффективность NАЦ (в дозе 3 мкг / кг в течение 24часовой внутри венной инфузии) при ЛПП, вызванном ХТ у 102 па циентов. Введение NАЦ приводило к более быстрому снижению показателей состояния печени по сравне нию с контрольной группой [29].…”

Section: аспекты поддерживающей терапииunclassified

Drug-induced liver injury in cancer patients

et al. 2020

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This review includes information about epidemiological data, development feature, phenotypes, principles of classification, diagnosis, and prognosis for drug-induced liver injury (DILI). Actual clinical recommendations regarding management of the DILI arising in the chemotherapy of cancer discussed. Drugs that can influence on individual pathogenetic mechanisms of growth and symptoms DILI are considered. Clinical studies for the prophylaxis and treatment of DILI associated with anticancer chemotherapy analyzed in detail. The prevention and treatment regimens for DILI in patients receiving chemotherapy and immunotherapy various localizations of cancer given both in research and in practical recommendations.

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Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury

Cited by 8 publications

References 32 publications

Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane

Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane

Use of eltrombopag and granulocyte colony‐stimulating factor in treatment of lomustine overdose in a dog

Drug-induced liver injury in cancer patients

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