Therapeutic effect of microcurrent on calf muscle atrophy in immobilized rabbit

Moon, Yun-Seob; Kwon, Dong Rak; Lee, Yoonjin

doi:10.1002/mus.26110

Cited by 9 publications

(28 citation statements)

References 26 publications

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“…Microcurrent therapy (MT) involves therapeutic application of very low electric current (<1 mA), which is usually sub-sensory for the body. A previous study demonstrated that MT might prevent progression of GCM muscle atrophy and facilitate the regeneration of muscle cells [13] . These effects could increase protein synthesis and stimulate satellite cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

Park¹,

Kwon²,

Moon³

2019

J Biomed Res

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The purpose of this study was to investigate the intensity-specific regenerative effects of microcurrent therapy on gastrocnemius muscle atrophy induced by cast-immobilization in rabbits. Fifteen rabbits were randomly allocated to 3 groups after cast removal: cast-immobilization and sham microcurrent therapy for 2 weeks (group 1); cast-immobilization and microcurrent therapy (25 μA) for 2 weeks (group 2); cast-immobilization and microcurrent therapy (5,000 μA) for 2 weeks (group 3). Clinical parameters [calf circumference, compound muscle action potential (CMAP) of the tibial nerve, thickness of gastrocnemius muscle], cross sectional area of gastrocnemius muscle fibres, and immunohistochemistry was evaluated. The clinical parameters representing mean atrophic changes in group 2 were significantly lower than those in group 3. The cross sectional area of the gastrocnemius muscle fibres and immunohistochemical parameters in group 2 were significantly greater than those in group 3. The results showed that low-intensity microcurrent therapy can more effectively promote regeneration in atrophied gastrocnemius muscle than high-intensity microcurrent therapy.

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Section: Introductionmentioning

confidence: 99%

Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

Park¹,

Kwon²,

Moon³

2019

J Biomed Res

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“…Deconditioning and reduced muscle activity is estimated to be the most important factors leading to muscle atrophy and loss of function in patients (31). In particular, the treatment of soft tissue and bone injuries by immobilization may result in skeletal muscle atrophy and decreased functional performance (32).…”

mentioning

confidence: 99%

“…Microcurrent therapy (MT) involves the therapeutic application of very low electric current (less than 1 mA), which is usually sub-sensory to the body. One study demonstrated that MT may prevent progression of GCM muscle atrophy and facilitate the regeneration of muscle cells (32). These effects may increase protein synthesis and stimulate satellite cell proliferation.…”

mentioning

confidence: 99%

“…The intensity of MT plays an important role in the effective treatment of muscle damage. Studies have shown that when an electric current with an intensity of less than 1,000 μA was applied for treating muscle damage which increases the adenosine triphosphate (ATP) production in the tissue and stimulates the amino acids incorporated into the protein in the tissue by 30-40% above the control level along with the activation of myogenic precursor cells (satellite cells) (32,33). On the other hand, when the intensity exceeded 1,000 μA, these bio-stimulatory effects were reversed.…”

mentioning

confidence: 99%

“…On the other hand, when the intensity exceeded 1,000 μA, these bio-stimulatory effects were reversed. One study using 25 μA to treat muscle atrophy reported good regeneration in vivo and in vitro (32). Therefore, it is suggested that a combination of microcurrent treatments may be helpful to prevent muscle atrophy caused by immobilization.…”

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confidence: 99%

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Adult mesenchymal stem cells for the treatment in patients with rotator cuff disease: present and future direction

Kwon

Park

2018

Ann. Transl. Med

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Effectiveness of combining microcurrent with resistance training in trained males

et al. 2019

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IntroductionMicrocurrent has been used to promote tissue healing after injury or to hasten muscle remodeling post exercise post exercise.PurposeTo compare the effects of resistance training in combination with either, microcurrent or sham treatment, on-body composition and muscular architecture. Additionally, changes in performance and perceived delayed onset muscle soreness (DOMS) were determined.MethodsEighteen males (25.7 ± 7.6 years) completed an 8-week resistance training program involving 3 workouts per week (24 total sessions) wearing a microcurrent (MIC, n = 9) or a sham (SH, n = 9) device for 3-h post-workout or in the morning during non-training days. Measurements were conducted at pre and post intervention.ResultsCompared to baseline, both groups increased (p < 0.05) muscle thickness of the elbow flexors (MIC + 2.9 ± 1.4 mm; SH + 3.0 ± 2.4 mm), triceps brachialis (MIC + 4.3 ± 2.8 mm; SH + 2.7 ± 2.6 mm), vastus medialis (MIC + 1.5 ± 1.5 mm; SH + 0.9 ± 0.8 mm) and vastus lateralis (MIC + 6.8 ± 8.0 mm; SH + 3.2 ± 1.8 mm). Although both groups increased (p < 0.01) the pennation angle of vastus lateralis (MIC + 2.90° ± 0.95°; SH + 1.90° ± 1.35°, p < 0.01), the change measured in MIC was higher (p = 0.045) than that observed in SH. Furthermore, only MIC enlarged (p < 0.01) the pennation angle of brachialis (MIC + 1.93 ± 1.51). Both groups improved (p < 0.05) bench press strength and power but only MIC enhanced (p < 0.01) vertical jump height. At post intervention, only MIC decreased (p < 0.05) DOMS at 12-h, 24-h, and 48-h after performing an exercise-induced muscle soreness protocol.ConclusionA 3-h daily use of microcurrent maximized muscular architectural changes and attenuated DOMS with no added significant benefits on body composition and performance.

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Therapeutic effect of microcurrent on calf muscle atrophy in immobilized rabbit

Abstract: MES prevents muscle atrophy and facilitates regeneration of muscle. Muscle Nerve 58: 270-276, 2018.

Cited by 9 publications

References 26 publications

Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

Adult mesenchymal stem cells for the treatment in patients with rotator cuff disease: present and future direction

Effectiveness of combining microcurrent with resistance training in trained males

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