Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges

Hosseini-Asl, Seyed-Kazem; Mehrabani, Davood; Karimi‐Busheri, Feridoun

doi:10.3390/jcm9123922

Cited by 24 publications

(37 citation statements)

References 90 publications

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“…Based on their satisfactory immunomodulatory effect, MSCs have been studied as a promising candidate for treating some inflammatory and immunologic diseases, such as graftversus-host disease (GvHD), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and ARDS (18)(19)(20)(21). As has been clarified, MSCs control both innate and adaptive immune response behavior through release of trophic factors, which are mediated by cell-contact-dependent and -independent mechanisms through the direct cell-cell interaction (22).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 Patient

Zhang

Huang

et al. 2021

Front. Med.

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Here we report a critically ill patient who was cured of SARS-CoV-2 infection in Changsha, China. A 66-year-old Chinese woman, with no significant past medical history, developed severe pneumonia-like symptoms and later diagnosed as severe COVID-19 pneumonia. Within 2 months of hospitalization, the patient deteriorated to ARDS including pulmonary edema and SIRS with septic shock. When treatment schemes such as antibiotics plus corticosteroids showed diminished therapeutic value, hUCMSC therapy was compassionately prescribed under the patient's consent of participation. After treatment, there was significant improvement in disease inflammation-related indicators such as IL-4, IL-6, and IL-10. Eventually, it confirmed the therapeutic value that hUCMSCs could dampen the cytokine storm in the critically ill COVID-19 patient and modulated the NK cells. In the continued hUCMSC treatment, gratifying results were achieved in the follow-up of the patient. The data we acquired anticipate a significant therapeutic value of MSC treatment in severe and critically ill patients with COVID-19, while further studies are needed.

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Section: Discussionmentioning

confidence: 99%

Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 Patient

Zhang

Huang

et al. 2021

Front. Med.

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“…Mesenchymal stem cells (MSCs) have the potential to differentiate into cell types that can repair damaged mucosa, via inhibition of inflammatory factors and downregulation of inflammatory response [ 79 ]. A systematic review and meta-analysis confirmed the effectiveness and safety of MSCs in the treatment of UC [ 80 ], indicating that targeted MSCs hold promise for future application [ 81 ]. In a rat experiment induced by TNBS/ethanol enema, intragastric TXYF was administered once a day for 28 days.…”

Section: Pathophysiological Studiesmentioning

confidence: 99%

Tong Xie Yao Fang: A Classic Chinese Medicine Prescription with Potential for the Treatment of Ulcerative Colitis

Kai

Lou

Zhu

2021

Evidence-Based Complementary and Alternative Medicine

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The prescription of Tong Xie Yao Fang (TXYF) was derived from the Yuan dynasty “Dan Brook Heart Law,” which was a representative formula for treating liver-spleen disharmony, diarrhea, and abdominal pain. The prescription is composed of four herbs for soothing the liver and strengthening the spleen. TXYF is reportedly capable of eliminating discomfort in ulcerative colitis (UC). This classic formula has been widely used for regulating gastrointestinal motor dysfunction and repairing colon mucosa. This review aims to provide current information on the pharmacology and clinical research of TXYF in the treatment of UC, and to critically appraise that information, in order to guide the future clinical use and experimental study of TXYF in the treatment of UC. We searched online databases including PubMed, CNKI, and Google Scholar for research published between 2010 and 2020 on TXYF and its efficacy in the treatment of UC. The findings indicated that TXYF has anti-inflammatory and immunomodulatory effects, regulates cell signal transduction, brain-gut axis, and intestinal flora in UC, and may promote targeting of bone mesenchymal stem cells (BMSCs) to the colonic mucosa and accelerate healing of the colonic mucosal barrier. In addition, the results of clinical studies showed that TXYF has good efficacy and few adverse reactions in the treatment of UC. Although it has achieved some success, the research is limited by deficiencies; there is a lack of unified standards for the construction of UC animal models and for administration regimen. In addition, the dosage of TXYF is not consistent and lacks pharmacological verification, and clinical trial data are not detailed or sufficiently rigorous. Therefore, a more rigorous, comprehensive, and in-depth study of TXYF in the treatment of UC is needed.

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“…In otorhinolaryngology, biocompatible scaffolds have been used to establish a normal structure and function in an injured tissue [12]. Cell transplantation or cell therapy is the other branch utilized in regenerative medicine to modulate immune response and regenerate new tissues, via paracrine signaling, by use of various types of stem cells, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) [4]. In cell-based therapies, replacement of the lost or damaged tissues happens via engraftment of viable transplanted cells and stimulation of endogenous self-healing pathways by trophic factors [13,14].…”

Section: Regenerative Medicine and Cell Transplantation Conceptmentioning

confidence: 99%

“…Non-invasive procedures, such as computed tomography (CT) scan or magnetic resonance imaging (MRI), cannot provide enough resolution to determine most pathologies of the inner ear [53]. Therefore, transplantation of exogenous MSCs can take advantage of an array of stem cells from various tissue sources [4].…”

Section: Inner Ear and Hearing Lossmentioning

confidence: 99%

“…Conventional therapies for head and neck damaged tissues include artificial materials and grafts from other tissues [2], but grafts were shown to have limited availability and can lead to morbidity in the donor site [3], and the use of artificial materials can have the risk of infection and reaction by the immune system [1]. When grafts are undertaken, immunosuppressive drugs are needed that have limited availability in many regions [4]. To improve these limitations, regenerative medicine, by using cell transplantation, has opened a new therapeutic window, which is a novel and rapidly growing field in otorhinolaryngology, which targets the healing and replacement of injured tissues where no current standard therapy works to restore functions of otorhinolaryngology sites [5].…”

Section: Introductionmentioning

confidence: 99%

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Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

Kaboodkhani

Mehrabani

Karimi‐Busheri

2021

JCM

Self Cite

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Otorhinolaryngology enrolls head and neck surgery in various tissues such as ear, nose, and throat (ENT) that govern different activities such as hearing, breathing, smelling, production of vocal sounds, the balance, deglutition, facial animation, air filtration and humidification, and articulation during speech, while absence of these functions can lead to high morbidity and even mortality. Conventional therapies for head and neck damaged tissues include grafts, transplants, and artificial materials, but grafts have limited availability and cause morbidity in the donor site. To improve these limitations, regenerative medicine, as a novel and rapidly growing field, has opened a new therapeutic window in otorhinolaryngology by using cell transplantation to target the healing and replacement of injured tissues. There is a high risk of rejection and tumor formation for transplantation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs) lack these drawbacks. They have easy expansion and antiapoptotic properties with a wide range of healing and aesthetic functions that make them a novel candidate in otorhinolaryngology for craniofacial defects and diseases and hold immense promise for bone tissue healing; even the tissue sources and types of MSCs, the method of cell introduction and their preparation quality can influence the final outcome in the injured tissue. In this review, we demonstrated the anti-inflammatory and immunomodulatory properties of MSCs, from different sources, to be safely used for cell-based therapies in otorhinolaryngology, while their achievements and challenges have been described too.

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Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges

Cited by 24 publications

References 90 publications

Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 Patient

Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 Patient

Tong Xie Yao Fang: A Classic Chinese Medicine Prescription with Potential for the Treatment of Ulcerative Colitis

Achievements and Challenges in Transplantation of Mesenchymal Stem Cells in Otorhinolaryngology

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