Therapeutic effect of Linum usitatissimum L. in STZ-nicotinamide induced diabetic nephropathy via inhibition of AGE’s and oxidative stress

Abstract

The present study was aimed to evaluate the potential of petroleum ether and hydro-alcoholic extract of Linum usitatissimum (FPE and FHE) in STZ-nicotinamide induced diabetic nephropathy. GC-MS analysis of FPE revealed the presence of different fatty acids, heterocyclic compounds etc. Moreover, chromatography of FHE isolated Secoisolariciresinol diglycoside. After 30 days of STZ-administration, 100, 200 and 400 mg/kg of FPE and FHE were administered for 45 days. FPE and FHE produced significant attenuation in the glycemic status, renal parameter, lipid profile and level of antioxidant enzymes proving efficacy in diabetic nephropathy. Moreover, FPE and FHE produced significant reduction in the formation of AGEs in kidney. The results indicated that via amelioration oxidative stress and formation of AGEs, FPE and FHE produced significant nephroprotective effect in STZinduced diabetic nephropathy in rats.

Flaxseed Lignans and Polyphenols Enhanced Activity in Streptozotocin-Induced Diabetic Rats

“…Daily administration of LU6 indicated beneficial effects in reducing postprandial hyperglycemia, endogenous insulin secretion, and islet regeneration, which can decrease the risk of developing type II diabetes in patients with impaired glucose tolerance. Recently, Kaur et al [ 23 ] assessed the potential of petroleum ether and hydro-alcoholic extract of Linum usitatissimum L. in STZ–nicotinamide-induced diabetic nephropathy. The isolated flavonoids, saponins, and terpenoids produced substantial diminution in the glycemic index, level of antioxidant enzymes, renal function, and lipid profile through glycation end products and oxidative stress inhibition [ 23 ].…”

Dillenia indica L. attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats

“… 7 At the same time, the interactions of AGEs with their receptors alter intracellular signaling and enhance the release of pro-inflammatory cytokines and free radicals that contribute toward the pathology of diabetic complications. 8 , 9 , 10 This mutual interaction leads to the thickening of the basement membrane, altered filtration, and, ultimately, loss of glomerular function. 11 Therefore, drugs that either inhibit the formation of AGE or break AGE-induced cross-links have been shown to be renoprotective in experimental models of DN.…”

Ameliorative effect of Cephalandra indica homeopathic preparation in STZ induced diabetic nephropathy rats

“…Diabetes is a multifactorial disease that has a considerable adverse impact on health. In support of management of diabetes as well as of complications related to it [23], [24], [25], [26]. There is urgent need of critical pharmacological research to establish new agents with high therapeutic value and fewer side effects.…”