Therapeutic effect of implanted and non-invasive vagus nerve stimulation on heroin-induced anxiety

Yue, Yingbiao; Zou, Lina; Li, Hong; Lei, Yu; Ren, Zhouyang; Yang, Fazhen; Kong, Deshenyue; Re, Guo-Fen; Luo, Huayou; Zhang, Zunyue; Wang, Kunhua; Zhu, Mei

doi:10.1016/j.bbrc.2023.02.041

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…This includes investigating potential biomarkers and predictive factors for VNS responsiveness [ 89 ]. Novel VNS approaches, such as non-invasive vagus nerve stimulation (nVNS), are being studied to explore their effectiveness as a less invasive alternative to traditional VNS therapy [ 90 , 91 ]. Some studies are investigating the potential synergistic effects of combining VNS with other neuromodulation techniques or with specific ASMs to enhance seizure control [ 92 , 93 , 94 ].…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management

Ghosh,

Sinha,

Ghosh

et al. 2023

Brain Sciences

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Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial number of patients facing drug-resistant epilepsy. This comprehensive review explores innovative therapies for epilepsy management, focusing on their principles, clinical evidence, and potential applications. Traditional antiseizure medications (ASMs) form the cornerstone of epilepsy treatment, but their limitations necessitate alternative approaches. The review delves into cutting-edge therapies such as responsive neurostimulation (RNS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS), highlighting their mechanisms of action and promising clinical outcomes. Additionally, the potential of gene therapies and optogenetics in epilepsy research is discussed, revealing groundbreaking findings that shed light on seizure mechanisms. Insights into cannabidiol (CBD) and the ketogenic diet as adjunctive therapies further broaden the spectrum of epilepsy management. Challenges in achieving seizure control with traditional therapies, including treatment resistance and individual variability, are addressed. The importance of staying updated with emerging trends in epilepsy management is emphasized, along with the hope for improved therapeutic options. Future research directions, such as combining therapies, AI applications, and non-invasive optogenetics, hold promise for personalized and effective epilepsy treatment. As the field advances, collaboration among researchers of natural and synthetic biochemistry, clinicians from different streams and various forms of medicine, and patients will drive progress toward better seizure control and a higher quality of life for individuals living with epilepsy.

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Section: Vagus Nerve Stimulationmentioning

confidence: 99%

A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management

Ghosh,

Sinha,

Ghosh

et al. 2023

Brain Sciences

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Particle Swarm Algorithm-based External Programmer App for an Animal Vagal Nerve Stimulator

Shen,

Li,

Zhao

et al. 2023

2023 16th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI)

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The effect of sucrose consumption on eating behavior and depression during morphine withdrawal period in rats

Aslan,

Köksal,

Karaboğa

2024

MNM

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BACKGROUND: Sugary drink and junk food consumption increases during the withdrawal period, leading to subsequent psychological and metabolic alterations. OBJECTIVES: We aimed to investigate the relationship of sucrose consumption with serum insulin levels, leptin levels, brain Dopamine-2 receptor (D2R) expression, food consumption, and anxiety-depression findings in morphine-withdrawal rats. METHODS: Thirty-six male Wistar albino rats were divided into six groups: Control, sucrose-free, 5% sucrose, 10% sucrose, 20% sucrose, and an addiction test. Saline was intraperitoneally injected to the control group, and morphine was intraperitoneally injected to the other groups for 14 days. After 14 days, naloxone was administered to the addiction test group, and addiction symptoms were observed and this group was sacrificed on the same day. Other groups were fed ad libitum with different concentrations of sucrose solution for one week. Behavioral parameters were evaluated at the end of the experiment. Leptin and insulin concentrations in serum and D2R levels in brain tissues were detected using an enzyme-linked immunosorbent assay. D2R concentrations in brain tissues were evaluated utilizing immunohistochemistry. RESULTS: We observed decreased food consumption and increased fluid consumption in rats that consumed sucrose water during the withdrawal period. The level of depression and binge eating behavior was elevated in groups consuming sucrose, and the 10% sucrose group had the highest carbohydrate consumption and anxiety levels. In addition, the 10% sucrose group had the lowest brain D2R expression. The leptin level was highest in the 20% sucrose group. CONCLUSIONS: These results show the possible effects of sugary drinks consumed during the withdrawal period.

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Therapeutic effect of implanted and non-invasive vagus nerve stimulation on heroin-induced anxiety

Cited by 3 publications

References 47 publications

A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management

A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management

Particle Swarm Algorithm-based External Programmer App for an Animal Vagal Nerve Stimulator

The effect of sucrose consumption on eating behavior and depression during morphine withdrawal period in rats

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