Therapeutic Effect ofBroussonetia papyriferaandLonicera japonicain Ovalbumin-induced Murine Asthma Model

Abstract

Broussonetia papyrifera (L.) Vent. and Lonicera japonica Thunb. have been used in recent medicinal research for their antioxidative and anti-inflammatory properties. The present study investigated the therapeutic efficacy of B. papyrifera and L. japonica ethanolic extracts in a murine model of ovalbumin-induced asthma, in which intra-peritoneal (IP) injections and aerosol ovalbumin delivery were used to induce allergic asthma. Bronchioalveolar lavage fluid (BALF), serum samples, lungs and livers were collected from the experimental groups. In the groups treated with B. papyrifera and L. japonica extracts, CD3, CD4, serum IgE and IL-4 levels; activities of matrix metalloproteinase (MMP)-2 and MMP-9; and eotaxin levels in the BALF significantly decreased to near normal levels. Results of a histopathological analysis showed that the level of inflammation and mucous secretions reduced in the treated groups compared to the corresponding levels in the other groups. Moreover, results of a serum enzymatic analysis showed the non-toxic nature of the extracts in the B. papyrifera and L. japonica treated groups. Taken together, these results clearly indicate that the B. papyrifera and L. japonica extracts may be very effective against asthma and inflammation related diseases.

A network pharmacology-based analysis to distinguish the differences between Lonicerae Japonicae Flos and Lonicerae Flos

“…Therefore, LJF and LF act synergistically on the NF-κB signalling pathway but under different mechanisms. LJF has a considerable effect on ovalbumin-induced asthma in a rat model [32]. By contrast, research on LF is few and there is no study has directly demonstrated that whether the LF have an proportional effect on asthma or not.…”

Lonicerae Japonicae Flos and Lonicerae Flos: A Systematic Pharmacology Review

“…The water extracts of Lonicerae japonicae flos have significant anti-inflammatory effects on classical inflammatory models such as carrageenan/formaldehyde-induced rat paw swelling [ 50 ], mouse ear edema [ 13 , 51 ], cotton ball granulomatous hyperplasia, mouse cutaneous vascular hyperpermeability [ 52 ], and egg white-induced localized acute inflammation [ 53 ]. Furthermore, it also exhibits anti-inflammatory effect in rat cervicitis model [ 54 , 55 ], Escherichia coli -infected mouse model [ 56 ], excision wound model of infected rat [ 57 ], and ovalbumin-induced rat asthma model [ 58 ]. The mechanisms include inhibition of inflammatory factor synthesis/release, decreased expression of immune related molecules, and enzyme activities of matrix metalloproteinase.…”

Transcriptomics analysis reveals the effect of Broussonetia papyrifera L. fermented feed on meat quality traits in fattening lamb

“…Antioxidant activities have been described for related polyphenolic constituents extracted from the stem, bark and wood of B. papyrifera ( Xu et al, 2010 ). There is report about the radix of B. papyrifera that had the greatest antinociceptive and anti-inflammatory effects when different parts of the plant were compared as treatment for chemical-induced pain and inflammation in rodents ( Hong et al, 2013 ).…”