Therapeutic effect of hesperidin with reference to biotransformation, lysosomal and mitochondrial TCA cycle enzymes against 7,12-dimethylbenz(a)anthracene-induced experimental mammary cellular carcinoma

D-Pinitol prevents rat breast carcinogenesis induced by 7, 12 -Dimethylbenz [a] anthracene through inhibition of Bcl-2 and induction of p53, caspase-3 proteins and modulation of hepatic biotransformation enzymes and antioxidants

“…In general, carcinogens are converted into DNA reactive metabolites by phase I and phase II xenobiotic metabolizing enzymes that are involved in the activation and detoxification of xenobiotics [49]. In our study decreased activity of phase I enzymes were observed in cancer-bearing animals this might be the utilization of these enzymes to excrete the DMBA metabolites and this well in accordance with the recent findings of Nandakumar et al [50]. UDP-GT and GST are known to be important preneoplastic and neoplastic markers to evaluate the extent of free radical damage caused by exposure to various carcinogens [51].…”

“…UDP-GT and GST are known to be important preneoplastic and neoplastic markers to evaluate the extent of free radical damage caused by exposure to various carcinogens [51]. The increased activities of these enzymes in group II cancer-bearing animals might be due to the enhancement of the covalent binding of DMBA metabolites to cellular DNA and results in an increase in the degree of cell damage leading to neoplastic growth and the results obtained from our investigations are consistence with the earlier findings of Nandakumar et al [50]. Conversely, D-Pinitol administration to DMBA treated rats showed significant modulation in the activities of phase I and excellent induction in phase II enzymes when compared to the controls.…”

Therapeutic effect of Ananus comosus peel on breast cancer induced by 7, 12- dimethylbenz(α)anthracene

“…Uncontrolled increase of these highly reactive molecules lead to free radical mediated chain reactions of which indiscriminately damage proteins, lipids and DNA resulting at last resort in cell death (Lenaz, 2001). Higher amounts of PAH-DNA adducts have been found in human breast tumors than in normal breast tissues (Nandakumar et al, 2011). 7, 12-dimethylbenz(α)anthracene (DMBA) is one of the polycyclic aromatic hydrocarbon chemical groups.…”

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii

“…e) comparably with LPS. Increased lysosomal enzyme activity is accompanied by the release of lysosomal enzymes such as acid phosphatase (AP), used for the killing and digestion of microbial pathogens through phagocytosis . The higher the augmentation of AP activity, the greater the phagocytic stimulation and intracellular killing capacity .…”