Therapeutic Effect of Guava Fruit Extract on Cadmium Induced Toxicity in Developing Mus musculus

Asmatullah, Asmatullah; Ara, Chaman; Andleeb, Shagufta; Tahir, Maha; Zahid, Beenish; Arshad, Madeeha

doi:10.17582/journal.pjz/2018.50.3.929.939

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Sections were deparaffinized with xylene and rehydrated with alcohol and water. After rehydration, sections were stained with H&E stains and allowed to dry in a dust‐free environment (for more details, see our previous articles [Asmatullah et al, 2018 ]). Slides were examined under a microscope at 40 and 100× for further histopathological analysis.…”

Section: Methodsmentioning

confidence: 99%

Protective potential of fresh orange juice against zinc oxide nanoparticles‐induced trans‐placental and trans‐generational toxicity in mice

Ara,

Andleeb,

Ali

et al. 2023

Food Science & Nutrition

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Due to the emerging applications of nanoparticles, human exposure to nanoparticles is unavoidable, particularly to zinc oxide nanoparticles (ZnO NPs), owing to their wide range of usage. The ongoing study aimed to evaluate trans‐generational toxic potential of ZnO NPs through exposure to F0 mothers, in F1 pups and F1 mature offspring and the protective potential of fresh orange juice (OJ). Twenty‐eight F0 mothers were randomly allocated into four groups (n = 7), control; untreated, dose group; exposed to ZnO NPs, dose+antidote group; coadministered ZnO NPs + OJ, antidote group; OJ, during the organogenetic period. Fifty percent of F0 mothers were subjected to cesarean sections on the 18th day of gestation and F1 pups were recovered, macro‐photographed, and dissected for liver evisceration, while 50% of F0 mothers underwent standard delivery. After parturition, F1 offspring were examined, and the liver and blood samples were extracted. Observations showed that ZnO NPs exposure in F0 mothers in preparturition and postparturition resulted in decreased body weight, increased liver weight, and elevated levels of ALT and AST significantly p ≤ .05 as compared to the control and antidote groups. Histopathological analysis of maternal livers intoxicated with NPs showed the disruptive structure of central vein, hepatocytes, and Kupffer cells in F0 mothers, while F1 pups showed morphological deviations and distorted development of the liver tissue and congestion, in contrast to the control. F1 offspring of NPs exposed mothers, even at postnatal week 8 showed pyknotic nuclei and activated Kupffer cells in the liver sections against control. But in the case of the Dose+antidote group, alterations were less severe than in the dose group. It can be concluded that exposure to ZnO NPs instigates teratogenicity and hepatotoxicity in F1 pups, F0 mothers, and F1 offspring, respectively, while fresh orange juice acts as a remedial agent against the abovementioned toxicities.

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Section: Methodsmentioning

confidence: 99%

Protective potential of fresh orange juice against zinc oxide nanoparticles‐induced trans‐placental and trans‐generational toxicity in mice

Ara,

Andleeb,

Ali

et al. 2023

Food Science & Nutrition

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Black coffee mitigates diethyl phthalate disrupted folliculogenesis, reduced gonadotropins, and ovarian lesions in female albino mice

Ara

Asmatullah

Ramzan

et al. 2022

Environ Sci Pollut Res

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Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

Ali,

Awadalla,

Hamed

et al. 2024

Cardiovasc Toxicol

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Cadmium (Cd) is a dangerous heavy metal that is non-degradable in the environment. Many organs can accumulate Cd and adversely affect organ function and health. Cd is considered as a teratogenic and embryotoxic agent. This study aims to evaluate the teratogenicity of Cd at concentrations lesser than the permissible and its effects on the heart during chick embryogenesis. Fertilized eggs of the chick Gallus domesticus were divided into; control, saline injected and four experimental groups injected with single doses of 5, 25, 50 or 75 µM of CdCl2. Histological observations of the heart before hatching and the cardiomyocytes after hatching were recorded. Morphometric measurements of heart chambers were achieved at 3, 4 and 6 days of incubation. Electrocardiograph and respiratory rate were recorded at tenth day. Different cardiac problems had been brought on by Cd. In comparison to controls, the heart looked much larger, and in certain cases, growth retardation was seen. Degeneration in heart walls and malformations of dorsal aorta were noticed. Morphometrically, the width and wall thickness of heart chambers showed significant changes. Heart beats and respiratory rate significantly decreased compared to control. The cardiotoxic effect of Cd on heart compartments structure and function was dose dependent. One of Cd toxicity is its ability to induce cellular oxidative stress. The heart in particular is sensitive to oxidative stress. Cardiac oxidative stress might intensify heart failure and promote disease progression. Calcium is one of the components that is needed for normal heart work. Cd might interfere with calcium metabolism by removing it from the body.

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Therapeutic Effect of Guava Fruit Extract on Cadmium Induced Toxicity in Developing Mus musculus

Cited by 4 publications

References 14 publications

Protective potential of fresh orange juice against zinc oxide nanoparticles‐induced trans‐placental and trans‐generational toxicity in mice

Protective potential of fresh orange juice against zinc oxide nanoparticles‐induced trans‐placental and trans‐generational toxicity in mice

Black coffee mitigates diethyl phthalate disrupted folliculogenesis, reduced gonadotropins, and ovarian lesions in female albino mice

Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

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