Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig

Maekawa, Hiromi; Matsunobu, Takeshi; Tsuda, Hitoshi; Onozato, Kaoru; Masuda, Yukihiro; Tanabe, Tetsuya; Shiotani, Akiko

doi:10.1016/j.neuint.2009.02.011

Cited by 11 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Edaravone is reported to reduce the amount of oxidative DNA damage and lipid peroxidation in barotraumatic inner ear (Maekawa et al, 2009). Edaravone also suppresses streptomycininduced vestibulotoxicity, and protects the cochlea from acoustic trauma in guinea pigs (Horiike et al, 2003;Takemoto et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line

Chang

Lee

et al. 2015

Hearing Research

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line

Chang

Lee

et al. 2015

Hearing Research

View full text Add to dashboard Cite

“…However, the precise mechanism remains unknown. In our previous study of IEB, we suggested that disturbance of cochlear blood flow produced by intense pressure loading leads to lipid peroxidation of cochlear tissue and that outer hair cell (OHC) loss was seen 28 days after intense pressure loading (2).…”

mentioning

confidence: 99%

“…The animals were anesthetized by intraperitoneal injection of ketamine (50 mg/kg) and medetomidine (1.0 mg/kg), and then earplugs that restrict the movement of the tympanic membrane were inserted into the external auditory canal. The animals were then placed in a chamber, and the pressure was increased from 1 to 2 atmosphere pressure absolute (ATA) for a 3-s period and decreased to 1 ATA over a 2-s period (2). A value of 2 ATA is equivalent to pressure at a depth of 10 m in water, the average depth attained by most scuba divers.…”

mentioning

confidence: 99%

“…The ABR threshold was determined by measurement of wave III or IV, which reflect the neural activity of the cochlear nucleus and the superior olivary complex in response to sound stimulation, respectively. In our previous study, we found that the threshold shift remains nearly unchanged 35 days after pressure loading in cases of IEB (2). For histological assessment, 9 animals were randomly assigned to 1 of 3 groups (n = 3/group): T-817MA-treated group (T-817MA concentration, 0.2 mg/ mL), non-treated (distilled water) control group, and normal group.…”

mentioning

confidence: 99%

“…The T-817MA-treated and non-treated control animals were decapitated 1 h after pressure loading, and the expression of 8-hydroxy-2 deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, was examined immunohistochemically. This method precisely follows that described in a previous report (2). Chemical structure of T-817MA (A), scheme of study protocol (B), and effect of pressure loading on hearing threshold shifts in groups I (T-817MA concentration: 0.7 mg/mL), II (T-817MA concentration: 0.2 mg/mL), and III (control) (C -G).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig

et al. 2011

Self Cite

View full text Add to dashboard Cite

Abstract. T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer's disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure-induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity.

show abstract

Protective role of edaravone against neomycin‐induced ototoxicity in zebrafish

Choi

Chang

Jun

et al. 2013

J of Applied Toxicology

View full text Add to dashboard Cite

Aminoglycosides such as neomycin are one of the most commonly prescribed types of antibiotics worldwide. However, these drugs appear to generate free radicals within the inner ear, which can result in permanent hearing loss. We evaluated the effects of edaravone, a neuroprotective agent, on neomycin-induced ototoxicity in transgenic zebrafish. The 5-day post fertilization (dpf) zebrafish larvae were exposed to 125 μM neomycin and various concentrations of edaravone for 1 h. Hair cell survival was calculated as average numbers of the hair cells in the control group, which was not exposed to neomycin. Ultrastructural changes were evaluated using a scanning electron microscope (SEM) and transmission electron microscope (TEM). Edaravone protected against neomycin-induced hair cell loss in the neuromasts (1000 μM: 11.6 ± 1.1 cells, neomycin only: 5.5 ± 0.5 cells; n = 10, P<0.05) and decreased the TUNEL reaction for detecting apoptosis. In ultrastructural analysis, structures of mitochondria and hair cells within neuromasts were preserved in zebrafish exposed to 125 μM neomycin and 1000 μM edaravone for 1 h. Edaravone protected against neomycin-induced hair cell loss by preventing apoptosis.

show abstract

Therapeutic effect of edaravone on inner ear barotrauma in the guinea pig

Cited by 11 publications

References 19 publications

Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line

Protective role of edaravone against cisplatin-induced ototoxicity in an auditory cell line

Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig

Protective role of edaravone against neomycin‐induced ototoxicity in zebrafish

Contact Info

Product

Resources

About