Therapeutic effect of combined hyperbaric oxygen and radiation therapy for single brain metastasis and its influence on osteopontin and MMP‑9

Abstract

The present study aimed to investigate the therapeutic effect of combined hyperbaric oxygen and radiation therapy for the treatment of single brain metastasis (SBM), as well as its influence on osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9). A total of 86 patients with SBM and those included within the study were randomly divided into two groups. The control group was only treated with whole brain radiotherapy, while the observation group was treated with hyperbaric oxygenation combined with whole brain radiotherapy. OPN and MMP-9 expression was measured in each group by ELISA and the results prior to and following treatment were compared. The total effective rate (patients with complete remission, partial remission or stabilized lesions) in the observation group (95.3%) was significantly increased compared with the control group (67.4%). However, the OPN and MMP-9 protein levels observed in the observation group were significantly reduced compared with the control group (P<0.05). In addition, the quality of life and the incidence of adverse reactions in the observation group were significantly improved compared with the control group (P<0.05). For patients with SBM, hyperbaric oxygenation combined with radiotherapy may improve the efficiency of treatment and should be considered for further investigation and use within a clinical setting.

Brain Metastases: A Modern Multidisciplinary Approach

“…Alternately, up-front HBOT in combination with RT has been explored as a salvage therapeutic strategy on the premise delivering high concentrations of oxygen and reversing the effect of radiation-induced hypoxic microenvironment. Response rates, quality of life, and the incidence of adverse reactions in BM patients treated with HBOT plus RT were significantly improved compared with RT alone 40 . However, further clinical investigations are required for this technique.…”

Responses of matrix metalloproteinases to hyperbaric oxygen treatment: changing for good or ill?

“…MMP-9 is also implicated in neuronal apoptosis and cancer migration and invasion once it can digest cell surface adhesion molecules 11,57 . In this respect, HBO 2 was found to decrease MMP-9 expression and cell death in rat hippocampus after carbon monoxide poisoning 47 and to enhance the effect of radiation therapy in reducing circulating MMP-9 levels and tumor size in patients with single brain metastasis 12 . The MMP-2 appeared to show minor changes associated with HBO 2 and disease, being often regarded as nearly unresponsive to growth factors or cytokines 13 .…”

“…Studies on the effects of HBO 2 on MMPs have focused on a few MMP types, namely MMP-1, −2, −3, −8, −9, and −13 [3][4][5][6]8,[10][11][12]14,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] . In those studies, MMP-9 was the preferred target of investigation (52.9%), followed by MMP-2 (29.4%), MMP-3 (5.9%), MMP-1 (3.9%), MMP-13 (3.9%), and MMP-8 (3.9%).…”

“…Besides relieving hypoxia, HBO 2 is thought to act at cellular and molecular levels triggering tissue restorative pathways still poorly explored. Both human and animal studies have generated valuable insight into HBO 2 effects on normal and impaired physiological processes in diverse organs such as skin, brain, kidney, lung, heart, vessels, bone, and ligaments [3][4][5][6][7][8][9][10][11][12] . As HBO 2 applications have been expanding over time, accumulating data indicate that HBO 2 may be effective for the treatment of diseases involving disturbances in tissue repair and remodeling 3,7,10,11 .…”

Role of Ultrasound Imaging in the Prediction of TRIM67 in Brain Metastases From Breast Cancer

“…Brain metastases (BM) have gradually become the most common malignancy of the central nervous system, with 20–40% of patients with cancer developing BM ( 1 , 2 ). Primarily, BM arises from tumors in the lungs and the breast; however, they are observed at other sites as well ( 3 ). Annually, the global incidence of BM has progressively increased and is associated with a poor prognosis.…”