“…For those subjects who do not produce high levels of these cells, we suggest that enhancing this response could beneficial, possibly as a means of delivering BDNF to the site of injury. Other studies that support the role of BDNF in recovery after stroke showed that BDNF-expressing neural stem cells were beneficial (Chang et al, 2013), as were mesenchymal stem cells (Jeong et al, 2014). Methods such as the use of histone deacetylase inhibitors (Kim et al, 2009) or a CD28 superagonist, as have already been shown to be beneficial in experimental stroke (Na et al, 2015), are possible strategies to increase the number of Treg cells.…”