Therapeutic effect of Acacia nilotica pods extract on streptozotocin induced diabetic nephropathy in rat

Omara, Enayat A.; Nada, Somaia A.; Farrag, Ashraf; Sharaf, Walid M.; Toumy, Sayed A. El

doi:10.1016/j.phymed.2012.07.006

Cited by 49 publications

(29 citation statements)

References 39 publications

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“…The diabetic model, which was induced by STZ, also caused pathological changes in the kidney tissue. Diabetic nephropathy (DN) is a multi-factorial condition, in which chronic hyperglycemia and oxidative stress play crucial roles for its occurrence (3,31). Chronic elevation of blood glucose concentration in diabetes mellitus is involved in the formation of advanced glycation end-products (AGEs), the mitochondrial production of free radicals and finally in cell death and impaired renal function (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…Chronic increase in plasma glucose level or hyperglycemia leads to microvascular and macrovascular complications such as diabetic nephropathy, accelerated atherosclerosis, neuropathy and retinopathy (2). Diabetic nephropathy (DN), as one of the critical problems of long term diabetes mellitus is the most common cause of end stage renal disease (ESRD) and it is inevitable for patients with this complication to be on dialysis (2)(3)(4)(5). Approximately this problem has become a serious challenge to public healthcare system due to the very expensive and prohibitive cost of renal surgery and transplantation in all societies, even in developed countries (3,6).…”

Section: Introductionmentioning

confidence: 99%

“…Diabetic nephropathy (DN), as one of the critical problems of long term diabetes mellitus is the most common cause of end stage renal disease (ESRD) and it is inevitable for patients with this complication to be on dialysis (2)(3)(4)(5). Approximately this problem has become a serious challenge to public healthcare system due to the very expensive and prohibitive cost of renal surgery and transplantation in all societies, even in developed countries (3,6). Based on previous studies it has been shown that in the United States DN accounts for 35% of patients with ESRD (6).…”

Section: Introductionmentioning

confidence: 99%

“…Although angiotensin-converting enzyme (ACE) inhibi-tors and angiotensin II receptor blockers can ameliorate the progression of DN, there is no effective and specific treatment (11,12). Medicinal plants are good sources for finding new therapeutic chemicals (3). Several studies have been carried out on the anti-diabetic and renoprotective effects of various plants, which resulted in appropriate and acceptable outcomes (3,13,14).…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal plants are good sources for finding new therapeutic chemicals (3). Several studies have been carried out on the anti-diabetic and renoprotective effects of various plants, which resulted in appropriate and acceptable outcomes (3,13,14). Calendula officinalis L. (CO) commonly known as Marigold belongs to the Asteraceae (daisies) family and grows throughout Europe and North America.…”

Section: Introductionmentioning

confidence: 99%

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Controversial effects of Calendula officinalis L. on Biochemical and Pathological Factors of Nephropathy in Diabetic Wistar Rats

Salehi¹,

Moradkhani²,

Roushandeh³

et al. 2015

Avicenna J Med Biochem

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Background: Chronic hyperglycemia leads to microvascular and macrovascular complications such as diabetic nephropathy. Medicinal plants are good sources for finding new therapeutic chemicals to improve diabetes and relieve its symptoms. Objectives: The purpose of the present study was to evaluate the effect of the hydroalcoholic extract (300 mg/kg) of Calendula officinalis (marigold) on blood biochemical profiles and histopathological changes in kidney of streptozotocin-induced diabetic rats. Materials and Methods: Twenty male Wistar rats were divided to four groups: Normal control (NC), diabetic control (DC), normal C. officinalis (N+CO) 300 mg/kg, and diabetic C. officinalis (D+CO) 300 mg/kg. The rats were treated for a period of 13 weeks. Diabetes was induced by Streptozocin injection, intraperitoneally. Level of glucose, urea, creatinine and also total anti-oxidant capacity, malondialdehyde, total oxidant status in serum and histological alterations in the kidney were analyzed. Results: Level of serum glucose, urea, creatinine, malondialdehyde and total oxidant status were increased in diabetic rats, whereas, total anti-oxidant capacity was decreased compared to the control animals. Also, histological findings confirmed the absence of integrity in glomerulus and mass infiltration in kidney tissue in diabetic rats compared to the normal controls. Calendula officinalis extract had no effect on blood glucose, but it decreased blood urea nitrogen and creatinine, total oxidant status and malondialdehyde while it increased total anti-oxidant capacity in the diabetic extract-treated group when compared to diabetic rats. Calendula officinalis could not prevent nephropathy changes in the diabetic rats. Conclusions: Therefore, our results suggest that although administration of 300 mg/kg of Calendula officinalis extract showed salutary effects on anti-oxidant profile, yet its protective effects on anti-diabetic and regenerative properties on nephropathy were ambiguous and require more investigations.

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