Therapeutic Effect of 1-Adamantanamine Hydrochloride in Naturally Occurring Influenza A2/Hong Kong Infection

Galbraith, A. W.; Oxford, J. S.; Schild, G. C.; Potter, C. W.; Watson, G. I.

doi:10.1016/s0140-6736(71)92299-9

Cited by 41 publications

(13 citation statements)

References 9 publications

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“…Although amantadine hydrochloride both as a prophylactic and curative has been tried in the younger population by many workers it has given variable results and has not been tried in the elderly population. Clinical evidence supports the view that amantadine has a definite though marginal effect in shortening the duration of fever in influenza by some hours (Galbraith et al, 1971). Nevertheless, the lack of a consistent and rapid defervescence in the clinical trials affords little support for the wider use of amantadine in the therapy of influenza at present.…”

Section: Discussionmentioning

confidence: 97%

Influenza in a geriatric unit

Gowda

1979

Postgraduate Medical Journal

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Summary An outbreak of influenza A (resembling A/Victoria/3/75) occurred in 2 geriatric wards in February 1976 and, out of 19 patients, 3 died. Of the patients who were at risk, 30% were affected. Immunization for influenza in the elderly just before the winter is suggested. The procedure is simple and inexpensive. The recommendations of the DHSS (U.K.) for the use of influenza vaccine to practising doctors is, therefore, welcome. The suitable treatment appears to be that of repeated immunization with inactivated vaccine. Amantadine in the elderly population may also be effective, and is worthy of trial.

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Section: Discussionmentioning

confidence: 97%

Influenza in a geriatric unit

Gowda

1979

Postgraduate Medical Journal

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“…Amantidine has an antiviral action, particularly against influenza A2 virus (Galbraith, Oxford, Schild, Potter, and Watson, 1971), but its action in Parkinsonism is unknown (Parkes, Baxter, Curzon, Knill-Jones, Knott, Marsden, Tattersall, and Vollum, 1971). Creutzfeldt-Jakob disease is known to be transmissible (Gibbs, Gadjusek, Asher, Alpers, Beck, Daniel, and Matthews, 1968), but whether the action of amantidine in this condition is antiviral or metabolic is impossible to say.…”

Section: Discussionmentioning

confidence: 99%

Creutzfeldt-Jakob disease treated with amantidine: A report of two cases

Sanders

Dunn

1973

Journal of Neurology, Neurosurgery & Psychiatry

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“…[36][37][38][39][40] However, many of the earlier placebo-controlled studies that included children did not report agespecific response or adverse-event rates. Adverse events have been most accurately assessed and reported in adults.…”

Section: Amantadine Treatmentmentioning

confidence: 99%

Antiviral Therapy and Prophylaxis for Influenza in Children

2007

Pediatrics

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Antiviral agents are available that are safe and effective for the treatment and prophylaxis of influenza virus infections in children. The neuraminidase inhibitors (oseltamivir [Tamiflu] and zanamivir [Relenza]) are preferred agents because of current widespread resistance to the adamantanes (amantadine [Symmetrel] and rimantadine [Flumadine]). Therapy should be provided to children with influenza infection who are at high risk of severe infection and to children with moderateto-severe influenza infection who may benefit from a decrease in the duration of symptoms. Prophylaxis should be provided (1) to high-risk children who have not yet received immunization and during the 2 weeks after immunization, (2) to unimmunized family members and health care professionals with close contact with high-risk unimmunized children or infants who are younger than 6 months, and (3) for control of influenza outbreaks in unimmunized staff and children in an institutional setting. Testing of current H5N1 avian influenza virus isolates, the potential agents of pandemic influenza, suggests susceptibility to oseltamivir and zanamivir. Because no prospective data exist on the efficacy of these agents in humans for H5N1 strains, the dosage and duration of therapy in adults and children may differ from those documented to be effective for epidemic influenza strains. INTRODUCTIONAntiviral agents for treatment and prophylaxis of influenza are safe and effective in children. Annual immunization against influenza is the preferred strategy for prevention of infection, but certain situations exist in which the use of antiviral agents is beneficial.The morbidity and mortality of epidemic influenza in unimmunized children is substantial, particularly in those younger than 2 years. 1-5 The purpose of this report is to offer guidance regarding antiviral treatment and prophylaxis to clinicians caring for children during yearly influenza epidemics and to provide resources for information on antiviral treatment in the event of an influenza pandemic, because no prospective human data currently exist on which to base recommendations for treatment of infections caused by potential H5N1 pandemic influenza virus strains. All clinical reports from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time. ANTIVIRAL DRUGS FOR EPIDEMIC AND PANDEMIC INFLUENZAThe guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate.

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Therapeutic Effect of 1-Adamantanamine Hydrochloride in Naturally Occurring Influenza A2/Hong Kong Infection

Cited by 41 publications

References 9 publications

Influenza in a geriatric unit

Influenza in a geriatric unit

Creutzfeldt-Jakob disease treated with amantidine: A report of two cases

Antiviral Therapy and Prophylaxis for Influenza in Children

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