Therapeutic effect and safety of xiaoqinglong decoction and sanziyangqin decoction in children with cough variant asthma: a Meta-analysis

Abstract

Objective: To evaluate the therapeutic effect and safety of xiaoqinglong decoction and sanziyangqin decoction combined with western medicine in children with cough variant asthma. Methods: Using the computer to retrieve literatures in The databases CNKI, WangFangData, VIP and PubMed, which published in October 2022 about the relevant clinical research, according to the row of standards to determine the literature, extract the data, the use of the Cochrane bias risk assessment tools for quality assessment included in the article, by using RevMan 5.4.1 software for meta-analysis articles. Results: A total of 14 RCTs involving 1268 patients were included. The results of the Meta analysis showed that compared with the control group (the group using western medicine alone), the experimental group (the group using xiaoqinglong decoction and sanziyangqin decoction combined with western medicine) had significantly higher overall response rate and more improved pulmonary function parameters including forced expiratory volume in the first second, forced vital capacity and percentage of peak expiratory flow, as well as significantly lower incidence rate of adverse reaction.Conclusions: Xiaoqinglong decoction and sanziyangqin decoction combined with western medicine has a significant effect in children with cough variant asthma and can reduce the occurrence of adverse reactions.