Therapeutic drug monitoring (TDM) in treatment of a pregnant for 34 weeks with a diagnosis of gangrenous appendicitis, peritonitis

Abstract

This article describes the clinical case of acute gangrenous appendicitis in a pregnant woman, followed by antibiotic therapy with meropenem dose of 2 g I. V. q8h with therapeutic drug monitoring (TDM) management. Therapeutic drug monitoring may be helpful for special patient populations with large pharmacokinetic variability, which include pregnant women. The goal of therapeutic drug monitoring is to increase the effectiveness of therapy by adjusting the dose and dosage regimen, as well as reducing the likelihood of side effects.