Therapeutic drug monitoring and virological response at week 48 in a cohort of HIV‐1‐infected patients switching to dolutegravir/rilpivirine dual maintenance therapy (ANRS‐MIE‐BIRIDER study)
Florian Lemaitre,
Jennifer Lagoutte‐Renosi,
Marie‐Claude Gagnieu
et al.
Abstract:AimsDolutegravir (DTG) and rilpivirine (RPV) dual therapy is now recommended as a switch option in virologically suppressed HIV patients. Literature suggests that virological failure with dual therapy could possibly relate to subtherapeutic drug concentrations. In this study, we aimed at describing the DTG and RPV trough plasma concentrations (Cmin) and plasma HIV‐1 RNA viral load (VL) during maintenance dual therapy.MethodsWe performed a retrospective analysis of DTG and RPV therapeutic drug monitoring in peo… Show more
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