Therapeutic Biomarkers in Friedreich’s Ataxia: a Systematic Review and Meta-analysis
Maria Gavriilaki,
Evangelia Chatzikyriakou,
Maria Moschou
et al.
Abstract:Although a large array of biomarkers have been investigated in Friedreich’s ataxia (FRDA) trials, the optimal biomarker for assessing disease progression or therapeutic benefit has yet to be identified. We searched PubMed, MEDLINE, and EMBASE databases up to June 2023 for any original study (with ≥ 5 participants and ≥ 2 months’ follow-up) reporting the effect of therapeutic interventions on any clinical, cardiac, biochemical, patient-reported outcome measures, imaging, or neurophysiologic biomarker. We also e… Show more
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