Therapeutic benefits of liquorice in dentistry

Sidhu, Preena; Shankargouda, Swapnil; Rath, Avita; Ramamurthy, Priyadarshini Hesarghatta; Fernandes, Bennete; Singh, Ashish Kumar

doi:10.1016/j.jaim.2017.12.004

Cited by 62 publications

(49 citation statements)

References 65 publications

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“…Glycyrrhizin shows potential beneficial effects in orodental diseases. These effects are associated with anti adherence anti microbial and anti inflammatory properties of the compound [25]. A study has shown that the glycyrrhizin were used in treatment of neurological disorders such as schizophrenia, dementia and Alzheimer's disease [26].…”

Section: Resultsmentioning

confidence: 99%

An in silico Analysis of Protein Targeted by Glycyrrhizin in Common Dental Pathogens

Balamithra

Girija

Priyadharsini

2020

JPRI

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Glycyrrhizin is a phytocompound which is derived from Glycyrrhiza glabra. It is used in treating the upper respiratory tract disease like cough, bronchitis, laryngitis, sore throat, etc. It has various medicinal uses in rheumatism, peptic ulcers, asthma, allergies, and inflammation. Glycyrrhizin has been reported to possess antibacterial, antiviral, antioxidant, anti inflammatory properties. In view of the above facts, the present in silico study was designed to demonstrate the molecular mechanism underlying the antimicrobial activity of glycyrrhizin against common dental pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Treponema denticola, Enterococcus faecalis and Tannerella forsythia. The STITCH tool was used to identify the drug-protein interaction. The functional class of the protein was deduced using VICMPred, followed by the identification of epitopes on the virulence factors using BepiPred. Further, the subcellular location of the virulence factors were also studied using PSORTb software. The computational analysis performed identified several virulence factors viz., short chain dehydrogenase/reductase family oxidoreductase of Treponema denticola and D-mannonate oxidoreductase of Tannerella forsythia which were found to interact with glycyrrhizin. Interestingly, phosphopyruvate hydratase was found to be the protein present in all the five genera was shown to interact with glycyrrhizin. Thus the present study reveals the target proteins on the dental pathogens which were shown to interact with glycyrrhizin. Furthermore, experimental validation of the results are warranted to provide substantial details on the anti-microbial activity of glycyrrhizin against common dental pathogens.

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Section: Resultsmentioning

confidence: 99%

An in silico Analysis of Protein Targeted by Glycyrrhizin in Common Dental Pathogens

Balamithra

Girija

Priyadharsini

2020

JPRI

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“…Licorice is used for gastritis, ulcers, cough, bronchitis, and inflammation [9]. Licochalcone A is an oxygenated chalcone (a type of natural phenol) (Figure 1A) that can be isolated from the roots of Glycyrrhiza species (such as G. glabra , G. inflata , and G. eurycarpa ) which belong to the plant family of Fabaceae [10]. It has been demonstrated to possess antiviral [11] and antimicrobial activities [12].…”

Section: Introductionmentioning

confidence: 99%

Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation

et al. 2019

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Licochalcone A, a flavonoid extracted from licorice root, has been shown to exhibit broad anti-inflammatory, anti-bacterial, anticancer, and antioxidative bioactivity. In this study, we investigated the antitumor activity of Licochalcone A against human osteosarcoma cell lines. The data showed that Licochalcone A significantly suppressed cell viability in MTT assay and colony formation assay in osteosarcoma cell lines. Exposure to Licochalcone A blocked cell cycle progression at the G2/M transition and induced extrinsic apoptotic pathway in osteosarcoma cell lines. Furthermore, we found the Licochalcone A exposure resulted in rapid ATM and Chk2 activation, and high levels of nuclear foci of phosphorylated Chk2 at Thr 68 site in osteosarcoma cell lines. In addition, Licochalcone A exposure significantly induced autophagy in osteosarcoma cell lines. When Licochalcone A-induced autophagy was blocked by the autophagy inhibitor chloroquine, the expression of activated caspase-3 and Annexin V positive cells were reduced, and cell viability was rescued in Licochalcone A-treated osteosarcoma cell lines. These data indicate that the activation of ATM-Chk2 checkpoint pathway and autophagy may contribute to Licochalcone A-induced anti-proliferating effect in osteosarcoma cell lines. Our findings display the possibility that Licochalcone A may serve as a potential therapeutic agent against osteosarcoma.

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“…GL ( 1 ) also possesses immunomodulatory, and neuroprotective effects [ 61 ] and antioxidant activities [ 62 , 63 ]. Furthermore GL ( 1 ) can be used in the clinical treatment of bronchitis, peptic ulcers, skin diseases, and oral diseases [ 56 , 64 , 65 ].…”

Section: Triterpene Saponins and Their Bioactivitiesmentioning

confidence: 99%

Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics

Liu

et al. 2020

Molecules

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Glycyrrhizae Radix et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, which are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid aglycone containing a hydrophilic sugar chain. This paper systematically summarizes the chemical structures of triterpene saponins in Glycyrrhizae Radix et Rhizoma and reviews and updates their main biological activities studies. Furthermore, the solubilization characteristics, influences, and mechanisms of Glycyrrhizae Radix et Rhizoma are elaborated. Solubilization of the triterpene saponins from Glycyrrhizae Radix et Rhizoma occurs because they contain the nonpolar sapogenin and water-soluble sidechain. The possible factors affecting the solubilization of Glycyrrhizae Radix et Rhizoma are mainly other crude drugs and the pH of the decoction. Triterpene saponins represented by glycyrrhizin from Glycyrrhizae Radix et Rhizoma characteristically form micelles due to amphiphilicity, which makes solubilization possible. This overview provides guidance regarding a better understanding of GlycyrrhizaeRadix et Rhizoma and its TCM compatibility, alongside a theoretical basis for the further development and utilization of Glycyrrhizae Radix et Rhizoma.

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Therapeutic benefits of liquorice in dentistry

Cited by 62 publications

References 65 publications

An in silico Analysis of Protein Targeted by Glycyrrhizin in Common Dental Pathogens

An in silico Analysis of Protein Targeted by Glycyrrhizin in Common Dental Pathogens

Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation

Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics

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