Therapeutic approaches to pyogenic granuloma: an updated review

Abstract

Pyogenic granuloma is a benign vascular proliferation of the skin and mucous membranes, whose pathogenesis is not fully understood. Despite its benign nature, it can have a significant negative impact on patients’ quality of life, and therefore appropriate therapy is needed. Over the years, a lot of therapeutic modalities have been used in order to successfully treat this condition. This paper is an updated systematic overview of all the reported successful treatments described in the literature and was conducted according to the PRISMA guidelines for systematic reviews. Articles derived from the databases PubMed, EMBASE, and SCOPUS, published between 1981 and 2018, were analyzed for this study. In the literature, there are several studies, case series, and case reports that demonstrate encouraging results with the use of various methods, such as surgical intervention or laser treatment, but also with more conservative approaches, including the application of topical and systemic agents. The selection of the appropriate treatment should be made individually, depending on severity of the disease and patient characteristics. Both research efforts as well as clinical reporting are necessary in order to provide more insight on the management of these vascular tumors. This paper aims to provide a summarized update on the reported therapies and to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate and compare the effectiveness of the presented therapeutic strategies.

Topical brimonidine for pyogenic granuloma after paronychia surgery

“…PG is a disorder of benign vascular proliferation, with rapidly growing erythematous nodules developing into pedunculated tumors that may be subject to erosion and bleeding. 7 The exact pathogenic mechanism is not fully clear and has been associated with trauma, infection, foreign body reactions, pregnancy, immunosuppression, several drugs, and delayed wound healing. 2 , 8 The current available treatment options include topical or systemic pharmacotherapies, silver nitrate, surgical intervention, semi-invasive therapies, laser, and others.…”

Pyogenic granuloma and nodular Kaposi’s sarcoma: dermoscopic clues for the differential diagnosis

“…Discussion PG is a benign vascular lesion mainly affecting the fingers, but it can affect all parts of the skin and mucous membranes. PG can usually be correctly diagnosed with history and the clinical appearance of the lesion [1]. However, it can also easily be misdiagnosed due to its nonspecific clinical morphology.…”

Modern classification of hemangiomas

“…Дольчаста капілярна гемангіома (піогенна гранульома, гранульоматозна телеангіоектазія) -відносно часта патологія, як у дітей, так і дорослих [49]. Вона найчастіше уражає шкіру та слизові мембрани [10].…”