“…Therefore, a major challenge for the field is learning more about clinical predictors or biomarkers of response as well as improving its efficacy. The observation of hypoactivity in the prefrontal cortex of depressed patients led George et al (2015) to evaluate the effectiveness of focal stimulation by TMS for enhancing activity in this region and combatting depression. Our understanding of the neural circuitry engaged by TMS has come a long way since then.…”