Therapeutic Applications of Noninvasive Neuromodulation in Children and Adolescents

Camsari, Deniz Doruk; Kirkovski, Melissa; Croarkin, Paul E.

doi:10.1016/j.psc.2018.05.003

Cited by 20 publications

(13 citation statements)

References 80 publications

(90 reference statements)

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“…Therefore, these approaches may also be promising in terms of improving clinical and cognitive ADHD symptoms such as inattention and impulsiveness. 258 260 261 262 Based on a meta-analysis, Westwood et al 263 suggested that left and/or right prefrontal stimulation may improve performance in attention, inhibition and/or working memory tasks. However, these approaches are not yet recommended by therapy guidelines.…”

Section: Treatmentmentioning

confidence: 99%

ADHD: Current Concepts and Treatments in Children and Adolescents

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is among the most frequent disorders within child and adolescent psychiatry, with a prevalence of over 5%. Nosological systems, such as the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and the International Classification of Diseases, editions 10 and 11 (ICD-10/11) continue to define ADHD according to behavioral criteria, based on observation and on informant reports. Despite an overwhelming body of research on ADHD over the last 10 to 20 years, valid neurobiological markers or other objective criteria that may lead to unequivocal diagnostic classification are still lacking. On the contrary, the concept of ADHD seems to have become broader and more heterogeneous. Thus, the diagnosis and treatment of ADHD are still challenging for clinicians, necessitating increased reliance on their expertise and experience. The first part of this review presents an overview of the current definitions of the disorder (DSM-5, ICD-10/11). Furthermore, it discusses more controversial aspects of the construct of ADHD, including the dimensional versus categorical approach, alternative ADHD constructs, and aspects pertaining to epidemiology and prevalence. The second part focuses on comorbidities, on the difficulty of distinguishing between “primary” and “secondary” ADHD for purposes of differential diagnosis, and on clinical diagnostic procedures. In the third and most prominent part, an overview of current neurobiological concepts of ADHD is given, including neuropsychological and neurophysiological researches and summaries of current neuroimaging and genetic studies. Finally, treatment options are reviewed, including a discussion of multimodal, pharmacological, and nonpharmacological interventions and their evidence base.

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Section: Treatmentmentioning

confidence: 99%

ADHD: Current Concepts and Treatments in Children and Adolescents

et al. 2020

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“…To compute the sum of contributions (15) for all source triangles and for all required target points, we apply the FMM approach three times, following the transform introduced in Eqs. (12) and (13), respectively.…”

Section: Fast Multipole Methods For the Total Potential (Eeg) And Totamentioning

confidence: 99%

Solving High-Resolution Forward Problems for Extra- and Intracranial Neurophysiological Recordings Using Boundary Element Fast Multipole Method

Hämäläinen

Okada

et al. 2019

Preprint

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We present a general numerical approach for solving the forward problem in high-resolution. This approach can be employed in the analysis of noninvasive electroencephalography (EEG) and magnetoencephalography (MEG) as well as invasive electrocorticography (ECoG), stereoencephalography (sEEG), and local field potential (LFP) recordings. The underlying algorithm is our recently developed boundary element fast multipole method (BEM-FMM) that simulates anatomically realistic head models with unprecedented numerical accuracy and speed. This is achieved by utilizing the adjoint double layer formulation and zeroth-order basis functions in conjunction with the FMM acceleration. We present the mathematical formalism in detail and validate the method by applying it to the canonical multilayer sphere problem. The numerical error of BEM-FMM is 2-10 times lower while the computational speed is 1.5-20 times faster than those of the standard first-order FEM. We present four practical case studies: (i) evaluation of the effect of a detailed head model on the accuracy of EEG/MEG forward solution; (ii) demonstration of the ability to accurately calculate the electric potential and the magnetic field in the immediate vicinity of the sources and conductivity boundaries; (iii) computation of the field of a spatially extended cortical equivalent dipole layer; and (iv) taking into account the effect a fontanel for infant EEG source modeling and comparison of the results with a commercially available FEM. In all cases, BEM-FMM provided versatile, fast, and accurate high-resolution modeling of the electromagnetic field and has the potential of becoming a standard tool for modeling both extracranial and intracranial electrophysiological signals.

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“…The dorsolateral prefrontal cortex (DLPFC) is perhaps the most commonly targeted frontal region for TMS research. This is due to its critical involvement in numerous cognitive processes (Balconi, 2013;Brunoni & Vanderhasselt, 2014), its well established role as an efficacious clinical target for major depressive disorder (Perera et al, 2016), having been trialled as a potential target for numerous conditions and disorders with neurobiological underpinnings (Doruk Camsari, Kirkovski, & Croarkin, 2018), and ease of access. The effects of TBS to the DLPFC as measured by fMRI, however, are inconsistent.…”

Section: Tbs To the Prefrontal Cortexmentioning

confidence: 99%

A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)

Kirkovski¹,

Donaldson²,

Michael³

et al. 2020

Preprint

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Theta burst stimulation (TBS) is associated with a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post TBS in healthy human adults. Forty-two studies that applied either continuous- or intermittent- (c/i) TBS, and adopted a pretest-posttest and/or sham-controlled design, were included. For resting-state outcomes following stimulation applied to motor, temporal, parietal, occipital, or cerebellar regions, functional connectivity generally decreased in response to cTBS and increased in response to iTBS, though there were some exceptions to this pattern of response. This is mostly consistent with the assumed long-term depression (LTD)/long-term potentiation (LTP)-like plasticity effects of cTBS and iTBS, respectively. Task-related outcomes following TBS were more variable. TBS applied to the frontal cortex, irrespective of task or state, also produced more variable responses, with no consistent patterns emerging. Individual participant and methodological factors are likely to contribute to the variability in responses to TBS. Future studies assessing the effects of TBS via fMRI must account for factors known to affect the response to TBS, both at the level of individual participants and of research methodology.

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Therapeutic Applications of Noninvasive Neuromodulation in Children and Adolescents

Cited by 20 publications

References 80 publications

ADHD: Current Concepts and Treatments in Children and Adolescents

ADHD: Current Concepts and Treatments in Children and Adolescents

Solving High-Resolution Forward Problems for Extra- and Intracranial Neurophysiological Recordings Using Boundary Element Fast Multipole Method

A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI)

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