Therapeutic applications of nanozymes and their role in cardiovascular disease

Abstract

Applications of magnetic nanoparticles include cell separation, nucleic acid separation, wastewater treatment, biomedical separation, magnetic target drug delivery, catalysis [4]. However, to broaden the applications of nanozymes, it is synergistically important to combine the activity of enzymes with properties of nanoscale such as optics, magnetic, mechanics, and electrics [2]. Many types of enzymes have been reported, and their applications in Environmental remediation, therapeutics, and biosensor development [6].

Metal-Based Nanoparticles for Cardiovascular Diseases

“…CeO 2 NPs can also dramatically reduce the expression of pro-inflammatory cytokines, the buildup of 3-nitrotyrosine, the infiltration of monocytes and macrophages, and apoptotic cell death, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the myocardium. It was determined that CeO 2 NPs inhibited the expression of important ER stress-associated genes, such as glucose-regulated protein 78 (Grp78), protein disulfide isomerase (PDI), and heat shock proteins (HSP25, HSP40, and HSP70) [118,119]. This suggests that CeO 2 NPs may prevent the development of cardiac dysfunction and remodeling by reducing inflammatory processes, ER stress, and myocardial oxidative stress, which is most likely due to their auto-regenerative antioxidant qualities [117,120].…”