Therapeutic applications of ginseng for skeletal muscle-related disorder management

Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights

“…Similarly, Rb1 suppresses ER stress-mediated inflammasome activation in adipose tissue, leading to decreased secretion of inflammatory cytokines and subsequent insulin resistance [ 45 ]. Moreover, Rb1 has been shown to have a great potential to suppress oxidative stress and inflammation in skeletal muscle in various disease models related to T2DM [ [46] , [47] , [48] ]. It is well recognized that both type 1 and type 2 diabetes are characterized by progressive pancreatic β cell failure [ 49 ], suggestive of the potential of targeting pancreatic β cell death as a therapeutic strategy to improve T2D.…”

Therapeutic Applications of Ginseng Natural Compounds for Health Management

“…In particular, ginseng has been administered as an herbal medicine for thousands of years and is now commercially available in pill and tea forms. Intriguingly, one clinical study reported that patients who took ginseng after curative surgery had a 38% higher overall survival rate and a 35% higher 5-year disease-free rate [19,121].…”

“…The use of Chinese medicine has risen in popularity after the 2015 Nobel Prize was awarded for the discovery that artemisinin is an effective treatment for malaria [6]. Ginseng (a medicinal herb) and its derived natural products are amongst the most popular natural remedies and are used to treat various diseases and conditions such as diabetes [7], anti-oxidative [8], inflammation [9], cancers [10], fungal, bacterial, viral, stress [11], and neurodegenerative diseases (ND) [12], as well as brain ischemia [13], hypertension [14], obesity [15], cardiovascular diseases and stroke [16], sarcopenia [17], muscle-wasting conditions [18][19][20], muscle aging, and cancer cachexia [21][22][23]. Known side effects of ginseng include headaches, diarrhea, blood pressure changes, skin irritations, and vaginal bleeding [24].…”