Therapeutic applications of bronchoalveolar lavage

Danel, Claire; Israël‐Biet, Dominique; Costabel, Ulrich; Klech, H

doi:10.1183/09031936.93.05101173

Cited by 29 publications

(4 citation statements)

References 17 publications

(18 reference statements)

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“…Bronchoscopy findings that indicate inhalation injury include erythema, oedema, mucosal blisters, erosions, TA B L E 1 Grading for inhalation injury on bronchoscopy (Albright et al, 2012). often utilised to diagnose infections but also has therapeutic relevance, particularly whole-lung lavage, in cases of inhalation injury (Danel et al, 1992;Vymazal & Krecmerova, 2015). Saline is used to flush the contaminant materials from the lung until the fluid runs clear (Awab et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Foncerrada et al (2018) demonstrated that secretions, damaged mucosa, pathogens, and aspirated material must be cleared from lungs that have sustained inhalation injury. Bronchoalveolar lavage (the washing of lung segments) is often utilised to diagnose infections but also has therapeutic relevance, particularly whole‐lung lavage, in cases of inhalation injury (Danel et al, 1992; Vymazal & Krecmerova, 2015). Saline is used to flush the contaminant materials from the lung until the fluid runs clear (Awab et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Inhalation injury in 11 Thoroughbred racehorses: Clinical course on bronchoscopy, treatment and postinjury racing performance

Tokushige

Kobayashi

Iimori

et al. 2023

Equine Veterinary Education

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SummaryInhalation injury is a serious and potentially fatal consequence of a fire or explosion. Bronchoscopy is recommended for rapid assessment of inhalation injury in humans; however, descriptions of bronchoscopic observation of inhalation injury in horses are lacking. We describe the clinical course of inhalation injury observed by bronchoscopy, treatment, and racing performance in 26 Thoroughbred racehorses that had been exposed to a fire. On initial bronchoscopy, 11 were diagnosed with inhalation injury (3 of Grade 1 [mild]; 3 of Grade 2 [moderate]; 4 of Grade 3 [severe]; and 1 of Grade 4 [massive]); 11 had no injury (Grade 0); and 4 were found dead. Treatment was based on inhalation injury grade and mainly involved airway lavage via bronchoscopy for soot removal and exudate recovery. Of the 11 horses with inhalation injury, 10 survived and 9 returned to racing. No effects in terms of racing performance (number of starts, finishing position, and earnings) were observed. Prompt and repeated bronchoscopy may be useful for evaluating the severity of inhalation injury, and airway lavage via bronchoscopy may be an effective treatment. If diagnosed and treated early and appropriately, even severe inhalation injury will not necessarily hinder postinjury racing performance in Thoroughbred racehorses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhalation injury in 11 Thoroughbred racehorses: Clinical course on bronchoscopy, treatment and postinjury racing performance

Tokushige

Kobayashi

Iimori

et al. 2023

Equine Veterinary Education

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“…FBC with TBB and BALF sampling were performed according to our society's recommendations [10]. After inspecting the airways, three 50 mL aliquots were administered into the segmental bronchi.…”

Section: Methodsmentioning

confidence: 99%

A Combination of Cytological Biomarkers as a Guide in the Diagnosis of Acute Rejection in Lung Transplant Recipients

et al. 2023

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The usefulness of bronchoalveolar lavage fluid (BALF) to support the diagnosis of acute cellular (ACR) rejection in lung transplant (LTX) recipients remains controversial. ACR has been associated with blood eosinophil counts (EOS) in other solid organ recipients, but there are few studies in relation to lung transplants. Our aim was to assess the usefulness of the combined analysis of BALF cellularity and EOS for the diagnosis of ACR in lung transplant recipients. This is a retrospective study of findings observed simultaneously in 887 transbronchial biopsies (TBB), BALF, and blood samples obtained from 363 LTx patients transplanted between 2014 and 2020. The variables collected were: demographics, ACR degree, BALF cellularity, and simultaneous blood EOS counts. The lymphocyte count in BALF was significantly higher in patients with ACR than in those without (11.35% vs. 6.11%; p < 0.001). In parallel, EOS counts were also significantly higher in patients with ACR than in the non-ACR group (EOS 213 ± 206/mm3 vs. 83 ± 129/mm3; p < 0.001). Increases in both parameters were associated with an increased risk of ACR (lymphocytes OR 1.100; 95% CI 1.080–1.131; EOS OR 1.460; 95% CI 1.350–1.580). The diagnostic specificity of ACR for a lymphocyte count > 12% was 71.1%, which increased to 95.8% when taking into account a simultaneous blood EOS count > 200/mm3. Simultaneous assessment of BALF lymphocyte counts and blood eosinophil counts may be useful for diagnosing ACR in patients with risk factors for TBB or in the presence of inconclusive histological samples.

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“…Studies in other airways diseases have been very limited [3). The findings of bronchoscopy and associated techniques are not diagnostic in asthma and the therapeutic use of bronchoalveolar lavage or bronchial aspiration is still controversial [2,4). Thus, investigative bronchoscopy, apart from individual therapeutic applications, is of very little clinical value in asthma [1,2), but it can be productively used as a tool for clinical studies.…”

Section: Background and Perspectivesmentioning

confidence: 99%