Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review

Mitchell, Steven D.; Sidiropoulos, Christos

doi:10.3390/toxins13030226

Cited by 9 publications

(5 citation statements)

References 70 publications

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“…Botulinum neurotoxin is effective in the treatment of sialorrhea, hyperhidrosis, gastrointestinal dysfunction and urinary dysfunction. Other symptoms of botulinum neurotoxin in Parkinson's disease include pain and movement symptoms such as blephaospasm, cervical dystonia, cervical dystonia, limb dystonia, and tremors [42]. Botulinum toxin is effective in the management of primary and secondary Raynaud's phenomenon [43].…”

Section: Resultsmentioning

confidence: 99%

Epidemiological aspects of poisoning Infectious-toxic bacteria of botulism on food poisoning in Iran; A review study

Mirbehresi

Pirhadi

Shokri

et al. 2022

Egyptian Journal of Veterinary Sciences

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B OTULISM is a rare neuroparalytic syndrome, caused by a neurotoxin produced by bacteria of the genus Clostridium. Signs and symptoms of food botulism begin 12 to 36 hours after the toxin enters the bloodstream .Clostridium botulinum is one of the most common life-threatening agents worldwide, producing the botulinum neurotoxin (BoNT). Poisoning is caused by the consumption of a highly toxic exotoxin produced during the growth of microorganisms in food. The growth of Clostridium botulinum strains and their production of toxins in vacuum processed foods have received special attention. Symptoms of botulism may appear 12 to 72 hours after eating foods that contain toxins, such as canned tuna, local dairy products, and home-made or commercial foods. Symptoms of poisoning include nausea, vomiting, bruising, dizziness and headache, dry skin, sore throat, constipation, mild fever (or no fever), muscle paralysis, diplopia, and eventually respiratory problems and death. On the other hand, botulinum neurotoxin is used in medicine and psychiatry. BoNT is involved in the management and control of many diseases such as depression and Parkinson's, dermatitis such as psoriasis, as well as in the beauty and elimination of facial skin wrinkles.

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Section: Resultsmentioning

confidence: 99%

Epidemiological aspects of poisoning Infectious-toxic bacteria of botulism on food poisoning in Iran; A review study

Mirbehresi

Pirhadi

Shokri

et al. 2022

Egyptian Journal of Veterinary Sciences

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“…Die Sialorrhoe stellt die häufigste Indikation zur BoNT-Therapie, die als Folge der oropharyngealen Dysphagie entsteht. Bei der oropharyngealen Dysphagie konnte durch die Injektion des M. cricopharyngeus und bei der ösophagealen Dysphagie in den oberen oder unteren Ösophagussphinkter eine Verbesserung der Symptomatik erreicht werden [51][52][53][54]. Diesbezüglich wurden nur Fallberichte und kleinere Fallsammlungen publiziert, sodass keine offizielle Zulassung besteht.…”

Section: Gastrointestinaltraktunclassified

Einsatzmöglichkeiten des Botulinum- Neurotoxins bei der Parkinson-Krankheit

Jost,

Berberovic

2024

Nervenheilkunde

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ZUSAMMENFASSUNGBotulinum-Neurotoxin (BoNT) wird seit den 1990er-Jahren in mehreren medizinischen Disziplinen zur Therapie unterschiedlicher Symptome (Spastik, Dystonien, Schmerzen, Sialorrhoe, etc.) eingesetzt und stellt bei etlichen Indikationen die Therapie der Wahl dar. Es hemmt die Freisetzung von Acetylcholin an den motorischen Nerventerminalen und parasympathischen Ganglien, und führt somit zu einer verminderten Aktivierung der behandelten Muskeln bzw. zur Reduktion der autonomen Funktion des behandelten Gewebes. Im Rahmen der Parkinson-Krankheit (PK) wird es zur Therapie motorischer und nicht motorischer Symptome eingesetzt. Für einige Symptome der PK besteht eine Zulassung für die Therapie mit dem BoNT. Für weitere Symptome, die außerhalb der PK vorkommen können, besteht ebenfalls eine Zulassung. Jedoch sind stellenweise die Zulassungen so eng gefasst, dass die spezielle Indikation bei der PK damit nicht der Zulassung entspricht. Im folgenden Text werden die einzelnen Indikationen zur Therapie mit dem BoNT bei der PK vorgestellt.

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“…Botulinum toxin A (BoNT-A) is occasionally used to treat sialorrhea or dystonic symptoms in PD [ 110, 111 ]. Its effect on parkinsonian upper limb tremor was investigated in open-label studies and one randomized, placebo-controlled study ([ 112 ], see Supplementary Material ).…”

Section: Drugs Targeting Pd Tremor: Evidence From Trialsmentioning

confidence: 99%

Pharmacological Treatment of Tremor in Parkinson’s Disease Revisited

Pirker¹,

Katzenschlager

Hallett

et al. 2023

JPD

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The pathophysiology of Parkinson’s disease (PD) tremor remains incompletely understood and there is a lack of clinical trials specifically addressing its pharmacological treatment. Levodopa is the most efficacious drug for most patients and should be used as primary approach to control troublesome tremor. While the efficacy of oral dopamine agonists on PD tremor has been demonstrated in controlled trials, there is no evidence of greater antitremor efficacy compared to levodopa. The magnitude of the antitremor effect of anticholinergics is generally lower than that of levodopa. Due to their adverse effects, anticholinergics have a limited role in selected young and cognitively intact patients. Propranolol may improve resting and action tremor and may be considered as an adjunct in patients with insufficient tremor response to levodopa and this also applies to clozapine, despite its unfavorable adverse effect profile. Treating motor fluctuations with MAO-B and COMT inhibitors, dopamine agonists, amantadine, or on-demand treatments such as subcutaneous or sublingual apomorphine and inhaled levodopa as well as with continuous infusions of levodopa or apomorphine will improve off period tremor episodes. For patients with drug-refractory PD tremor despite levodopa optimization deep brain stimulation and focused ultrasound are first-line considerations. Surgery can also be highly effective for the treatment medication-refractory tremor in selected patients without motor fluctuations. The present review highlights the clinical essentials of parkinsonian tremor, critically examines available trial data on the effects of medication and surgical approaches and provides guidance for the choice of treatments to control PD tremor in clinical practice.

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Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review

Cited by 9 publications

References 70 publications

Epidemiological aspects of poisoning Infectious-toxic bacteria of botulism on food poisoning in Iran; A review study

Epidemiological aspects of poisoning Infectious-toxic bacteria of botulism on food poisoning in Iran; A review study

Einsatzmöglichkeiten des Botulinum- Neurotoxins bei der Parkinson-Krankheit

Pharmacological Treatment of Tremor in Parkinson’s Disease Revisited

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