Therapeutic Applications and Effects of Lupinus angustifolius (Blue Lupin) and Its Components: A Systematic Review and Meta-Analysis

Abstract

Lupinus angustifolius has a unique nutrient profile among legumes and may have beneficial health effects when included in the diet. The aim of this study was to investigate the biological properties of blue lupin (Lupinus angustifolius), its chemical components, and their relevance for monitoring biological and anthropometric health markers, including triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), BMI, weight, and glycemia, compared with control groups with other kinds of diets. PubMed, Web of Science, and Scopus databases, updated to December 2023, were searched. Out of the 194 studies identified, a total of 7 randomized controlled trials (RCTs) comprising 302 participants met the eligibility criteria. The results of our study indicated that the blue lupin diet has a direct relationship with parameters such as blood glucose, weight, and LDL-C but not with TGs or BMI. In conclusion, the research described in this review clearly indicates that L. angustifolius may play an important role in the dietary prevention of hyperlipidemia and hypertension. Therefore, it would be highly advisable to increase its consumption in diets. However, further studies, ideally in humans, are required to truly establish L. angustifolius’s health-promoting properties.

Liver Antioxidant Capacity and Steatosis in Laying Hens Exposed to Various Quantities of Lupin (Lupinus angustifolius) Seeds in the Diet

“…Lupin seeds are known to be rich in polyphenols, phytosterols, and squalene [12,19]. The most abundant phenolic compounds in L. angustifolius seeds are flavones, phenolic acids, and isoflavones, which represent 76%, 19%, and 4% of the total identified phenols, respectively [28]. Although many authors suggest that lupin is a good and inexpensive source of protein in the diet, which translates to health and production benefits in animals, our study confirms that as in other species, the flavonoids contained in lupin can significantly inhibit ECOD activity in the hepatic microsomes of laying hens.…”

“…Apart from toxic alkaloids, lupin also contains numerous phytochemicals, including polyphenols, phytosterols, and squalene [24,25]. In addition, lupin contains carotenoids, such as β-carotene and zeaxanthin [26][27][28]. The presence of phenolic compounds and carotenoids determines one of the most important properties of lupin, i.e., its antioxidant activity, owing to which its use as a feed supplement protects against oxidative stress and increases the body's ability to eliminate free radicals responsible for oxidation processes in cells [29].…”

Influence of Roasting Temperature on the Detectability of Potentially Allergenic Lupin by SDS-PAGE, ELISAs, LC-MS/MS, and Real-Time PCR

“…Due to the rather high content of essential amino acids, fortification of foods with lupin proteins not only increases their protein content but also their nutritional value [ 5 ]. Consumption of lupin seeds has been associated with a variety of health benefits, including hypoglycemic, hypocholesterolemic, and anti-inflammatory effects [ 5 , 6 , 7 , 8 ]. Since lupin protein isolates and concentrates show outstanding techno-functional properties, they are used to increase, e.g., water holding, emulsifying, and/or gelation capacity of food products [ 9 , 10 ].…”