Therapeutic application of manganese-based nanosystems in cancer radiotherapy

Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development

“…Initially, the tumor microenvironment's weak acidity, hypoxia, and high glutathione levels affect radiotherapy's outcomes. 63 Secondly, although hypoxic cells release more ROS than normal cells, studies indicate that under hypoxic conditions, the antioxidant defense network in hypoxic cells is more actively engaged, quickly diminishing ROS damage to tumor cells. 64 Additionally, the hypoxic conditions within tumors can stimulate the expression of hypoxia-inducible factor HIF-1, which in turn promotes tumor cell proliferation and survival.…”

Janus ACSP Nanoparticle for Synergistic Chemodynamic Therapy and Radiosensitization

“…Nanoradiosensitizers, mainly high Z nanomaterials, possessing much higher mass-energy coefficients for X-ray absorption and attenuation, can enhance intracellular radiation deposition and radiation-induced tumor cell killing and regulate the tumor microenvironment. , Various multifunctional radiosensitive nanomaterials have been investigated based on Au, Bi, Gd, Hf, and other high-Z elements. − The newly emerging nanomaterial-mediated radiosensitive agents show quite obvious synergy between radiation and other treatment modalities, such as catalyzing ROS generation, regulating the cell cycle, adjusting signal pathways, enhancing photothermal therapy, and so on. − In addition, the high atomic number characteristic enables imaging guidance.…”