Abstract:The growing understanding of the molecular mechanisms of carcinogenesis accelerated the development of monoclonal therapeutic antibodies to specifically target multiple cancer pathways. Recombinant protein therapeutics now constitute a large proportion of yearly approved medicines. Oncology, autoimmune diseases and to a smaller degree the prophylaxis of organ transplant rejection are their main application areas. As of the date of this review, 37 monoclonal antibody products are approved for use in cancer trea… Show more
“…The review by Eltarhoni et al [6] provides an overview of the development and use of monoclonal therapeutic antibodies to target multiple cancer pathways. The authors thoroughly discuss the molecular mechanisms of carcinogenesis and how this understanding has led to the development of recombinant protein therapeutics, which now constitute a large proportion of yearly approved medicines.…”
“…The review by Eltarhoni et al [6] provides an overview of the development and use of monoclonal therapeutic antibodies to target multiple cancer pathways. The authors thoroughly discuss the molecular mechanisms of carcinogenesis and how this understanding has led to the development of recombinant protein therapeutics, which now constitute a large proportion of yearly approved medicines.…”
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