Therapeutic antibodies: A new era in the treatment of respiratory diseases?

Sécher, Thomas; Guilleminault, L.; Reckamp, Karen L.; Amanam, Idoroenyi; Plantier, Laurent; Heuzé-Vourc’h, Nathalie

doi:10.1016/j.pharmthera.2018.05.003

Cited by 34 publications

(36 citation statements)

References 222 publications

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“…Respiratory diseases entail conditions such as chronic obstructive pulmonary disease (COPD), asthma, occupational lung diseases, and pulmonary hypertension [1]. Globally, these diseases affect millions of people across diverse ages and account for significant levels of disability and mortality especially in children less than 5 years [2][3][4][5]. The occurrence and severity of respiratory diseases remain high in both developed and developing countries.…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Survey of Plants Used for Treating Cough Associated with Respiratory Conditions in Ede South Local Government Area of Osun State, Nigeria

Lawal

Olufade

Rafiu

et al. 2020

Plants

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In many developing countries, community members depend on their local flora for treating diverse ailments including those affecting the respiratory system. This is often attributed to the high cost and limited access to health care facilities. This present study focused on the documentation of plant species used against cough associated with the respiratory diseases in Ede South Local Government Area of Osun State. The survey was conducted using semi-structured interviews among 100 participants. Information obtained was analyzed using different ethno-botanical indices including relative frequency of citation (RFC) and fidelity level (FL). A total of 87 plant species from 39 families, which was mostly represented by Fabaceae, were reported in the study area. Crinum jagus was the most popular plant used against cough and approximately 32% of the plants have been reported as cough remedies for the first time. However, some of the documented plants have been reported for the treatment of cough and related respiratory diseases in several countries. In terms of the life-form, trees constituted the highest proportion of the medicinal plants (37%), while leaves (36%) were the predominant plant part prescribed for cough. Decoction was the main method of preparing the plants, which were all administered orally. Approximately 63% of the plants were exclusively sourced from the wild. The current study revealed the richness and widespread use of plant species for managing cough associated with respiratory diseases in the study area. The generated inventory contributes to the expanding database of valuable plant resources with medicinal potential in Nigeria and Africa.

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Section: Introductionmentioning

confidence: 99%

Ethnobotanical Survey of Plants Used for Treating Cough Associated with Respiratory Conditions in Ede South Local Government Area of Osun State, Nigeria

Lawal

Olufade

Rafiu

et al. 2020

Plants

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“…In view of their advantageous pharmacological features, protein therapeutics (including antibodies) have ushered in a new era in respiratory medicine; they provide significant clinical benefit and are becoming increasingly important tools in the therapeutic armamentarium [1]. Given the limited diffusion of protein therapeutics from the bloodstream to the lungs (partly due to their high molecular weight), pulmonary delivery of aerosolized proteins seems an obvious choiceprovided that the therapeutic target operates in the lungs, of course [2].…”

Section: Advances In Inhaled Protein Therapeutics For Topical Deliverymentioning

confidence: 99%

Designing inhaled protein therapeutics for topical lung delivery: what are the next steps?

Bodier-Montagutelli

Mayor

Vecellio

et al. 2018

Expert Opinion on Drug Delivery

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Drug delivery in the airways by inhalation can be used for local and/or systemic action, depending on the ability of the aerosolized drug to cross the air-blood barrier. For proteins, this is partly conditioned by the drug's molecular weight, as well as aerosol characteristics. This editorial focuses on protein inhalation for topical delivery purposes. Even though systemic applications (such as insulin inhalation) are not considered herein, it is worth noting that systemic diffusion following topical delivery may happen in some cases, and provide therapeutic benefit (as is the case for granulocyte-macrophage colony-stimulating factor (GM-CSF)).

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“…The impracticality to measure large numbers of missense‐mutated peptides chosen from these GWAS studies hampers an assessment from a technical point of view. Also the possible presence of neoantigens in COPD and lung cancer is hampered by the sensitivity of mass spectrometry to detect and identify peptides derived of neoantigens and it is even debated if neoantigens exist in COPD …”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

“…Research by Lambrechts and co‐workers showed that rs1051730 on chromosome 15q24/25 is associated with the presence and severity of emphysema and they discussed a shared pathogenic mechanism in COPD and lung cancer . As mentioned above, anti‐PD‐L1 antibody (e.g., atezolizumab) has revolutionized the treatment of NSCLC patients and has been approved in 2016 by the U.S. Food and Drug Administration. For COPD such a treatment does not yet exist and therapeutic antibodies to proteins of the innate system (cytokines) have not proven to be successful .…”

Section: Genomicsmentioning

confidence: 99%

Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View

Zeneyedpour

Dekker

Hoff

et al. 2019

Proteomics Clinical Apps

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The goal of this manuscript is to explore the role of clinical proteomics for detecting mutations in chronic obstructive pulmonary disease (COPD) and lung cancer by mass spectrometry‐based technology. COPD and lung cancer caused by smoke inhalation are most likely linked by challenging the immune system via partly shared pathways. Genome‐wide association studies have identified several single nucleotide polymorphisms which predispose an increased susceptibility to COPD and lung cancer. In lung cancer, this leads to coding mutations in the affected tissues, development of neoantigens, and different functionality and abundance of proteins in specific pathways. If a similar reasoning can also be applied in COPD will be discussed. The technology of mass spectrometry has developed into an advanced technology for proteome research detecting mutated peptides or proteins and finding relevant molecular mechanisms that will enable predicting the response to immunotherapy in COPD and lung cancer patients.

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Therapeutic antibodies: A new era in the treatment of respiratory diseases?

Cited by 34 publications

References 222 publications

Ethnobotanical Survey of Plants Used for Treating Cough Associated with Respiratory Conditions in Ede South Local Government Area of Osun State, Nigeria

Ethnobotanical Survey of Plants Used for Treating Cough Associated with Respiratory Conditions in Ede South Local Government Area of Osun State, Nigeria

Designing inhaled protein therapeutics for topical lung delivery: what are the next steps?

Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View

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