Therapeutic Angiogenesis With Autologous Hepatic Tissue Implantation and Omental Wrapping

Shao, Zhanqiang; Kawasuji, Michio; Takaji, Kentaro; Katayama, Yoshihiko; Matsukawa, Masakazu

doi:10.1253/circj.cj-08-0167

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…Results of angiogenesis and formation of blood vessels in the current study which showed profound capillary buds in OD comparing to HD and CD. The mechanism of omentum-induced angiogenesis is due to several growth factors mainly vascular endothelial growth factor (VEGF) and Fibroblast growth factor (FGF) [25]. Formation of new capillaries and blood vessels plays a key role in wound healing process and preventing infection through increasing host defence mechanisms in wounded area.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Omental and Hypericum Perforatum Extracts on Healing of Full Thickness Excisional Skin Wounds in Rabbits

Alnajjar

2025

Egyptian Journal of Veterinary Sciences

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NVESTIGATING clinical and histopathological effects of the topical application of Hypericum and omental extracts on healing in skin wound of the rabbits. Fifteen rabbits were divided into 3groups (4, 7, and 14-day intervals). In each animal, three circular excisions about 2cm were created, Control defect (CD), Hypericum defect (HD), and Omental defect (OD). Defects were observed clinically for rates of contraction. Biopsies were taken for histopathological examinations; sections were stained with H&E and Mason's trichrome stains. Clinical comparison at 4 days interval showed no significant differences among three groups. At 7 days interval showed significant decrease in size of HD comparing to CD at p-value (0.0132), while there were no significant differences between HD and OD between neither CD nor OD. At 14 days interval, the difference between HD and CD was highly significant (pvalue 0.0024), between HD and OD was significant (pvalue 0.0290), while between OD and CD was not significant (p value 0.3717). Histopathological examinations showed increased, number of fibroblasts and collagen, and angiogenesis rate, at 7-day interval and more re-epithelialization at 14-day interval in HD and OD comparing to the CD. It was concluded from results that there were positive effects of Hypericum and Omental extracts on healing process through increasing.

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Section: Discussionmentioning

confidence: 99%

Comparison Between Omental and Hypericum Perforatum Extracts on Healing of Full Thickness Excisional Skin Wounds in Rabbits

Alnajjar

2025

Egyptian Journal of Veterinary Sciences

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“…Taheri et al [86] suggested that omentopexy and cell patch cardiomyoplasty in conjunction with CABG may stimulate myogenesis and angiogenesis in avascular, dyskinetic scar tissue of left ventricle. Shao et al [87] concluded that hepatic tissue implantation combined with omental wrapping attenuated left ventricular remodeling and improved cardiac function. Although the exact mechanism is not completely understood, there is some evidence suggests that neovascularization increases through a process which is mediated by lipid angiogenic factors liberated by the omentum [88].…”

Section: The Limitation and Perspectives Of Cardiac Tissue Engineeringmentioning

confidence: 99%

The Current Status of Engineering Myocardial Tissue

Sui

Liao

Zhou

et al. 2010

Stem Cell Rev and Rep

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Myocardial infarction (MI) remains a common fatal disease all over the world. The adult cardiac myocytes regenerative capability is very limited after infarct injury. Heart transplantation would be the best therapeutic option currently but is restricted due to the lack of donor organs and the serious side effects of immune suppression. The emerging of tissue engineering has evolved to provide solutions to tissue repair and replacement. Engineering myocardial tissue is considered to be a new therapeutic approach to repair infarcted myocardium and ameliorate cardiac function after MI. Engineering myocardial tissue is the combination of biodegradable scaffolds with viable cells and has made much progress in the experimental phase. However, the largest challenge of this field is the revascularization of the engineering constructs to provide oxygen and nutrients for cells. This review will give an overview on the current evolution of engineering myocardial tissue and address a new method to improve the vascularization of myocardium tissue in vivo.

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