Therapeutic and Symptomatic Treatment of Multiple Sclerosis

Rosenblum, David S.; Saffir, Michael

doi:10.1016/s1047-9651(18)30251-1

Cited by 9 publications

(3 citation statements)

References 74 publications

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“…It appears to have some benefit in fatigue, though its mechanism of action is unknown. 47 It is usually taken at a dosage of 200 mg/day 4 and is quite well tolerated, though possible adverse effects include ankle oedema with livedo reticularis, diminished concentration, nervousness and sleeping disturbances. 4 Several RCTs investigating its effect were initially found.…”

Section: Amantadine (Symmetrel ® )mentioning

confidence: 99%

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Treatments for fatigue in multiple sclerosis: a rapid and systematic review.

Brañas¹,

Jordan²,

Fry‐Smith³

et al. 2000

Health Technology Assessment

264

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T he overall aim of the NHS R&D Health Technology Assessment (HTA) programme is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and work in the NHS. Research is undertaken in those areas where the evidence will lead to the greatest benefits to patients, either through improved patient outcomes or the most efficient use of NHS resources. The Standing Group on Health Technology advises on national priorities for health technology assessment. Six advisory panels assist the Standing Group in identifying and prioritising projects. These priorities are then considered by the HTA Commissioning Board supported by the National Coordinating Centre for HTA (NCCHTA). The research reported in this monograph was commissioned by the HTA programme (project number 99/05/05) on behalf of the National Institute for Clinical Excellence (NICE). Rapid reviews are completed in a limited time to inform the appraisal and guideline development processes managed by NICE. The review brings together evidence on key aspects of the use of the technology concerned. However, appraisals and guidelines produced by NICE are informed by a wide range of sources. Any views expressed in this rapid review are therefore those of the authors and not necessarily those of the HTA programme, NICE or the Department of Health. Reviews in Health Technology Assessment are termed 'systematic' when the account of the search, appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. Criteria for inclusion in the HTA monograph series Reports are published in the HTA monograph series if (1) they have resulted from work either prioritised by the Standing Group on Health Technology, or otherwise commissioned for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.

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Section: Amantadine (Symmetrel ® )mentioning

confidence: 99%

“…It was excluded because participants in the study were a subset of people with MS from another included study. 35 The third study 47 was a non-randomised controlled trial. Data from this study are presented in Table 22.…”

Section: Fatigue Assessment Instrumentmentioning

confidence: 99%

Treatments for fatigue in multiple sclerosis: a rapid and systematic review.

Brañas¹,

Jordan²,

Fry‐Smith³

et al. 2000

Health Technology Assessment

264

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“…Additionally, it is difficult to discern whether improvement following interventions may be due to confounding variables. For instance, some benefits could be conferred through social interactions during group exercise (Bigi and Yeh, 2013 ) or the yoga instructor serving as an encouraging mentor (Kishiyama et al, 2002 ). In many studies, participants were assigned to either a treatment or control group, though evidence supporting the outcome is stronger in three-arm trials with an alternate exercise group that serves as an active control to the yoga intervention (Senders et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Yoga as a method of symptom management in multiple sclerosis

Frank

Larimore

2015

Front. Neurosci.

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Multiple Sclerosis (MS) is an immune-mediated process in which the body's immune system damages myelin in the central nervous system (CNS). The onset of this disorder typically occurs in young adults, and it is more common among women. Currently, there is no cure and the long-term disease progression makes symptomatic management critical for maintaining quality of life. Several pharmacotherapeutic agents are approved for treatment, but many patients seek complementary and alternative interventions. Reviews have been conducted regarding broad topics such as mindfulness-based interventions for people diagnosed with MS and the impact of yoga on a range of neurological disorders. The objective of the present review is to examine the potential benefits of yoga for individuals with MS and address its use in managing symptoms including pain, mental health, fatigue, spasticity, balance, bladder control, and sexual function.

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Multiple Sclerosis: Management of Disease Complications

Stone¹

2003

Office Practice of Neurology

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Therapeutic and Symptomatic Treatment of Multiple Sclerosis

Cited by 9 publications

References 74 publications

Treatments for fatigue in multiple sclerosis: a rapid and systematic review.

Treatments for fatigue in multiple sclerosis: a rapid and systematic review.

Yoga as a method of symptom management in multiple sclerosis

Multiple Sclerosis: Management of Disease Complications

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