Therapeutic and preventative effects of ankaferd blood stopper in an experimental necrotizing enterocolitis model

Büyüktiryaki, Mehmet; Tayman, Cüneyt; Koyuncu, İsmail; Çakır, Ufuk; Türkmenoğlu, Tuğba Taşkın; Çakır, Esra; Okur, Nilüfer

doi:10.1016/j.biopha.2018.11.023

Cited by 14 publications

(26 citation statements)

References 35 publications

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“…The hemostatic, antimicrobial, antiinflammatory, regenerative, antioxidant, antiapoptotic, and antitumoral effects of ABS have been investigated in in vivo and in vitro studies [10][11][12][13][14][24][25][26][27]. In a study by Büyüktiryaki et al, ABS decreased the intestinal necrosis in a necrotizing enterocolitis rat model [28]. Beyazit et al reported that ABS reduced inflammation in the developed cervicitis rat model [29].…”

Section: Discussionmentioning

confidence: 99%

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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Background/aim To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing. Materials and methods A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program. P < 0.05 was considered significant. Results The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3, respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score, mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003). Conclusion ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.

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Section: Discussionmentioning

confidence: 99%

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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“…14 The potential beneficial effect of ABS might be associated with reduced TNF-a in this case. Buyuktiryaki et al 15 demonstrated that ABS reduced oxidative stress by enhancement of antioxidant activity. ABS was associated with remarkably lower TNF-a and interleukin-1 beta (b) levels, significant improvement in histopathological findings and reduced apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Their findings indicated that ABS protects against intestinal damage due to its antioxidant and anti-inflammatory properties. 15 In a clinical study, Patiroglu et al 16 disclosed the mucosal healing effects of ABS. ABS is effective in the prophylaxis and treatment of oral mucositis secondary to chemotherapy in childhood cancers.…”

Section: Discussionmentioning

confidence: 99%

Effective Ankaferd Hemostat Treatment For Severe Intractable Chronic Deep Leg Ulcer Associated With Behçet’s Disease

Çiftçiler

Haznedaroğlu

2019

Arch Rheumatol

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“…The intervention group resulted in a significantly reduced apoptosis rate and a reduction in the intestinal lesions. Given the above, the antioxidant, anti-inflammatory, and anti-apoptotic intestinal properties reduced the NEC in this specific context [28] [ Table 2].…”

Section: Pre-clinical Trialsmentioning

confidence: 99%

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

et al. 2020

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Preterm birth (PTB), defined as parturition prior to 37 weeks of gestation, is the leading cause of morbidity and mortality in the neonatal population. The incidence and severity of complications of prematurity increase with decreasing gestational age and birthweight. The aim of this review study is to select the most current evidence on the role of oxidative stress in the onset of preterm complication prevention strategies and treatment options with pre-clinical and clinical trials. We also provide a literature review of primary and secondary studies on the role of oxidative stress in preterm infants and its eventual treatment in prematurity diseases. We conducted a systematic literature search of the Medline (Pubmed), Scholar, and ClinicalTrials.gov databases, retroactively, over a 7-year period. From an initial 777 articles identified, 25 articles were identified that met the inclusion and exclusion criteria. Of these, there were 11 literature reviews: one prospective cohort study, one experimental study, three case-control studies, three pre-clinical trials, and six clinical trials. Several biomarkers were identified as particularly promising, such as the products of the peroxidation of polyunsaturated fatty acids, those of the oxidation of phenylalanine, and the hydroxyl radicals that can attack the DNA chain. Among the most promising drugs, there are those for the prevention of neurological damage, such as melatonin, retinoid lactoferrin, and vitamin E. The microbiome also has an important role in oxidative stress. In conclusion, the most recent studies show that a strong relationship between oxidative stress and prematurity exists and that, unfortunately, there is still little therapeutic evidence reported in the literature.

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Therapeutic and preventative effects of ankaferd blood stopper in an experimental necrotizing enterocolitis model

Cited by 14 publications

References 35 publications

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Effective Ankaferd Hemostat Treatment For Severe Intractable Chronic Deep Leg Ulcer Associated With Behçet’s Disease

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

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