2015
DOI: 10.1111/andr.12058
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Therapeutic advances in the treatment of Peyronie's disease

Abstract: SUMMARYPeyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase of PD, there are currently numerous available oral drugs, but the scientific evidence for their use is weak. In terms of intralesional injections, collagenase clostridium histolyticum is c… Show more

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Cited by 43 publications
(37 citation statements)
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References 122 publications
(153 reference statements)
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“…Prevalence of this disease varies between 3.6% and 13% as reported by various epidemiological studies. 1 4 It is, therefore, not as rare a disease as is generally believed; in fact, PD prevalence is much higher than that of diabetes mellitus, which was 2.8% in 2000 (the estimated prevalence for 2030 is 4.4%). 5 …”
Section: Introductionmentioning
confidence: 97%
“…Prevalence of this disease varies between 3.6% and 13% as reported by various epidemiological studies. 1 4 It is, therefore, not as rare a disease as is generally believed; in fact, PD prevalence is much higher than that of diabetes mellitus, which was 2.8% in 2000 (the estimated prevalence for 2030 is 4.4%). 5 …”
Section: Introductionmentioning
confidence: 97%
“…However, all these medicines have obvious side effects. Long-term consumption of vitamin E will cause nausea, vomiting, diarrhea, headache, dizziness, and cerebrovascular disorders, as well as increase the risk of cancers [16]. Pioglitazone belongs to PPAR-γ agonist thiazolidinedione and has many side effects [17], including weight gain, pedal edema, bone loss and heart failure [18].…”
Section: Introductionmentioning
confidence: 99%
“…Historically, the gold standard of PD treatment was surgery (Yafi, Pinsky, Sangkum, & Hellstrom, 2015). Over the years, many drugs were proposed as nonsurgical treatment of PD, being administered orally, with intraplaque injections, or by iontophoresis, without showing a clear benefit over placebo in penile curvature correction (Levine, 2007(Levine, , 2013Russell, Steers, & McVary, 2007;Yafi et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Historically, the gold standard of PD treatment was surgery (Yafi, Pinsky, Sangkum, & Hellstrom, 2015). Over the years, many drugs were proposed as nonsurgical treatment of PD, being administered orally, with intraplaque injections, or by iontophoresis, without showing a clear benefit over placebo in penile curvature correction (Levine, 2007(Levine, , 2013Russell, Steers, & McVary, 2007;Yafi et al, 2015). In contrast, in 2013 the Food and Drug Administration (FDA) approved the use of collagenase from Clostridium Histolyticum (CCH; Xiapex®, Swedish Orphan Biovitrium AB), along with penile modelling, as a therapeutic alternative in patients with PD in stable phase, palpable noncalcified plaque and penile curvature of at least 30º; after it was demonstrated in the IMPRESS I and II trials that it was a safe and effective treatment in this setting (Gelbard et al, 2013).…”
Section: Introductionmentioning
confidence: 99%