Therapeutic advances in immunosuppression

Thomson, Angus W.; Forrester, John V.

doi:10.1111/j.1365-2249.1994.tb05496.x

Cited by 7 publications

(4 citation statements)

References 72 publications

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“…Finally, we performed further experiments to determine whether other immunoregulatory mechanisms, such as involvement of CD4 + CD25 + regulatory T cells and co‐stimulatory molecules CTLA‐4, CD28, CD80 and CD40 [1–5], are also responsible for suppressing the immune response mediated by curcumin and resveratrol. Both drugs down‐regulated the expression of CD28 on CD4 + T cells and CD80 on macrophages.…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Sharma

Chopra

Kulkarni

et al. 2006

Clinical and Experimental Immunology

142

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SummaryThe role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.

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Section: Discussionmentioning

confidence: 99%

“…Change in the expression of co‐stimulatory molecules, secretion of cytokines and frequency of regulatory T cells can influence the outcome of many diseases. Modulation of the expression of CD28/CTLA‐4 can augment or antagonize T cell receptor signalling, and interleukin (IL)‐10 is known to restrain the immune responses [3–7].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Sharma

Chopra

Kulkarni

et al. 2006

Clinical and Experimental Immunology

142

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“…Indeed, the expression of CD28 and CD80 can be decreased by resveratrol and curcumin, while the production of CTLA‐4 and the IL‐10 is increased (Sharma et al., 2007). This modulation is significant since the T cell receptor signaling can be reduced or enhanced by the modification of the expression of CD28/CTLA‐4 and IL‐10 is known to limit the immune response (Akdis & Blaser, 2001; Ansari & Sayegh, 2006; Thomson & Forrester, 1994). Nuclear factors are also included because NF‐κB p65 nuclear translocation in activated CD4 + T‐cells is restrained in curcumin diets (W. Kim et al., 2009).…”

Section: Modulation Of Host Gut Microbiota By Dietary Polyphenolsmentioning

confidence: 99%

Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

et al. 2020

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The human gastrointestinal tract is inhabited by a vast number of microorganisms that are called as the microbiota. Each individual harbors a unique gut microbial composition, this composition evolves throughout the host's lifetime and it is easily affected by internal or external changes. It has been shown that gut microbiota plays a crucial role in host's health and as this complex community has the ability to interact with each other and with the host's immune system, the presence or absence of some major species can affect the homeostasis. Diet can be considered as one of the pivotal factors in modulating the functionality, integrity, and composition of the gut microbiota as the gastrointestinal tract is the first organ exposed to components of the diet. In this review, we have focused on the effects of polyphenols, key compounds of a healthy diet with several biological activities, on the gut microbial composition, their biotransformation by the gut microbiota, and the effect of their reciprocal interactions in human health and disease. K E Y W O R D S biotransformation, gut microbiota, host health, polyphenolsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…For example, curcumin treatment in Min/+ mice increases mucosal CD4 + T cells and B cells and contribute to prevent adenoma formation [51]. This modulation is important since a modulation of the expression of CD28/CTLA-4 can augment or antagonize T cell receptor signaling, and interleukin (IL)-10 is known to restrain the immune response [53][54][55]. CD28/CTLA-4) and different transcription factors such as members of the signal transducers and activators of transcription (STAT) and the Nuclear Factor-κB (NFκB).…”

Section: Polyphenols and T Helpermentioning

confidence: 99%

Immunomodulation and Anti-inflammatory Roles of Polyphenols as Anticancer Agents

Ghiringhelli

Rébé²,

Hichami³

et al. 2012

ACAMC

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Cancers are the largest cause of mortality and morbidity in industrialized countries. Several new concepts have emerged in relation to mechanisms that contribute to the regulation of carcinogenesis processes and associated inflammatory effects such as the modulation of innate immune cells and adaptive immune cells that could infiltrate the tumor. In the tumor microenvironment, there is a delicate balance between antitumor immunity and tumor-originated proinflammatory activity, which weaken antitumor immunity. Consequently; modulation of immune cells and inflammatory processes represent attractive targets for therapeutic intervention in malignant diseases with the goal to restore the sensitivity of cancer cells to chemotherapies and to overcome resistance to current cytotoxic therapies. Numerous studies have reported interesting properties of dietary polyphenols in anticancer strategies notably by their pleiotropic properties on cancer cells, immune cells and inflammation. This review is dedicated to the current knowledge of the mechanisms of polyphenols (resveratrol, curcumin, genistein and epigallocatechin) against cancers through a modulation of the immune system and the pro-inflammatory mediator production. We describe the effects of polyphenols on the adaptative and innate immune cells that could infiltrate the tumor. Reduction of chronic inflammation or its downstream consequences may represent a key mechanism in the fight of cancer development and polyphenols could reduce various pro-inflammatory substance productions through targeting signal transduction or through antioxidant effects. Lastly, we analyze key molecular links between inflammation and tumor progression through nuclear factors such as NFκB or microRNAs.

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Therapeutic advances in immunosuppression

Cited by 7 publications

References 72 publications

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

Immunomodulation and Anti-inflammatory Roles of Polyphenols as Anticancer Agents

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