“…BRD4) (Tang et al, 2013) and EZH2 (Coward et al, 2018;Xiao et al, 2016) were identified. We chose to focus on pracinostat because it was most effective in our primary assay outcome, and because HDAC inhibition has proven effective in fibrosis models (Barter et al, 2010;Bombardo et al, 2018;Conforti et al, 2017;Glenisson et al, 2007;Guo et al, 2009;Kang et al, 2017;Khalil et al, 2015;Kim et al, 2018;Ota et al, 2015) but its anti-fibrotic effects remain poorly understood. However, we also note that inhibitors of several enzymes not previously linked to fibrosis were identified in our screen, such as L3MBTL3, a reader of methylated-lysine on histones (Min et al, 2007;Trojer et al, 2007).…”