Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH
Amaia Navarro-Corcuera,
Yiwei Zhu,
Fanglin Ma
et al.
Abstract:Background and Aims: Recent studies have highlighted the beneficial effect of resolvin D1 (RvD1), a DHA-derived specialized pro-resolving mediator, on metabolic dysfunction-associated steatohepatitis (MASH), but the underlying mechanisms are not well understood. Our study aims to determine the mechanism by which RvD1 protects against MASH progression. Methods: RvD1 was administered to mice with experimental MASH, followed by bulk and single-cell RNA sequencing analysis. Primary cells including bone marrow-deri… Show more
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