Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Souza, Priscila Soares de; Rocha, Luis Gustavo Costa da; Tromm, Camila Baumer; Scheffer, Débora da Luz; Victor, Eduardo Ghisi; Silveira, Paulo César Lock; Souza, Cláudio Teodoro de; Silva, Luciano Acordi da; Pinho, Ricardo A.

doi:10.1016/j.lfs.2012.06.028

Cited by 23 publications

(12 citation statements)

References 34 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The efferent renal arteriole demonstrates a constriction in response to glomerular endothelial injury [ 45 ] and may eventually contribute to further deterioration in eGFR and progression to renal microvascular disease [ 46 ]. A late-onset decrease in oxidative stress and increase in anti-oxidative factors due to exercise training could prevent progressive fibrosis in the kidneys [ 47 , 48 ]. Exercise-induced blood volume expansion likely contributes to increased renal blood flow and shear stress in the kidney at rest and during exercise [ 49 – 51 ], the latter stimulating improvements in endothelial function [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

The effects of aerobic exercise on eGFR, blood pressure and VO2peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis

et al. 2018

View full text Add to dashboard Cite

BackgroundCKD is associated with several comorbidities, cardiovascular disease being the most significant. Aerobic training has a beneficial effect on cardiovascular health in healthy and some well-defined non-healthy populations. However, the effect of aerobic training on glomerular filtration rate in patients with CKD stages 3–4 is unclear.ObjectiveTo review the effects of aerobic exercise training on kidney and cardiovascular function in patients with chronic kidney disease (CKD) stages 3–4.MethodsA random-effects meta-analysis was performed to analyse published randomized controlled trials through February 2018 on the effect of aerobic training on estimated glomerular filtration rate, blood pressure and exercise tolerance in patients with CKD stages 3–4. Web of Science, PubMed and Embase databases were searched for eligible studies.Results11 randomized controlled trials were selected including 362 participants in total. Favourable effects were observed on estimated glomerular filtration rate (+2.16 ml/min per 1.73m2; [0.18; 4.13]) and exercise tolerance (+2.39 ml/kg/min; [0.99; 3.79]) following an on average 35-week aerobic training program when compared to standard care. No difference in change in blood pressure was found.ConclusionsThere is a small beneficial effect of aerobic training on estimated glomerular filtration rate and exercise tolerance, but not on blood pressure, in patients with CKD stages 3–4. However, data are limited and pooled findings were rated as of low to moderate quality.

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of aerobic exercise on eGFR, blood pressure and VO2peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In rats, moderate-(65% VO 2max ) and high-intensity (75% VO 2max ) chronic aerobic exercise resulted in significantly increased SOD activity, compared to low-intensity (55% VO 2max ) and sedentary conditions [11] in the right ventricle of the heart. In addition, treadmill running performed for 8 weeks (50 min/day, 5 days/wk, 17 m/min) [24] and 14 weeks (60 min/day, 3 days/wk, 30 m/min) [25] resulted in significant increases in kidney-specific SOD activity [24] and CAT activity in the tibialis anterior [25], compared to sedentary rats. Although research suggests increases in exercise intensity results in increased levels of OS and INF, it is the repeated exposure to increased oxidative and inflammatory insult that seems to be responsible for positive exercise-induced adaptations, namely increases in eAO activity [11,25].…”

Section: Quantitative Reverse Transcription Polymerase Chain Reactionmentioning

confidence: 91%

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Tucker

Briskey

Scanlan

et al. 2015

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO 2 max), versus low intensity exercise (45-50% VO 2 max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation.Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (p<0.001). Compared to low intensity exercise, high intensity interval training resulted in increased mRNA expression of Cat (p<0.001) and Tnfrsf1b (p=0.047). In this study, high intensity interval training was superior to sedentary behaviour and low intensity exercise as high intensity interval training beneficially influenced expression of genes related to endogenous antioxidant enzyme activity and inflammation.

show abstract

“…In parallel to human data, swimming exercise in rats for 10 weeks increased SOD activity in the diaphragm and kidney (37). Treadmill exercise in rats with either chronic hypertension (38) or chronic renal disease was shown to increase SOD and GPx activity, but not the antioxidant effects of CAT, implicating that the protective effect of regular aerobic exercise on kidney damage occurs by up-regulating SOD and GPx activity (19). In the current study, exercise training did not alter RVHinduced depletion in renal SOD levels.…”

Section: Discussionmentioning

confidence: 65%

Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats

Kumral¹

2014

mpj

View full text Add to dashboard Cite

Epidemiological studies have shown that regular exercise and increased aerobic fitness are associated with a decrease in allcause mortality and morbidity, including diseases related with high blood pressure. However, whether exercise has an antiinflammatory impact on the pathogenesis of hypertension was not elucidated yet. In the present study, to investigate the potential protective and therapeutic effects of exercise training (swimming for 30 min/day, 5 days/week for 9 weeks) on renovascular hypertension (RVH) 10-week-old male Wistar albino rats were divided into 4 groups as sham-operated sedentary control group, sedentary group with RVH (2-Kidney, 1-Clip Goldblatt) and two exercised RVH groups, which had 9-week training either before the surgery or after the surgery. Systolic blood pressures (SBP) were measured by the tail-cuff method on a weekly basis and at the end of 12 weeks, rats were decapitated to obtain kidneys. SBP were significantly higher in the sedentary RVH group than the control group, whereas in the trained RVH group measurements were not different than those of the control animals. In the renal tissues of the sedentary RVH group, malondialdehyde and myeloperoxidase levels were increased with a concomitant decrease in glutathione levels, while in the trained RVH group the levels were not different than those of the control group. Moreover, in the trained RVH group, superoxide dismutase and catalase levels measured as antioxidant parameters, were also significantly increased as compared with those of the sedentary RVH group. Current results demonstrate that regular moderate training controls high blood pressure in RVH, while RVH-induced oxidative damage in renal tissue is ameliorated through the modulation of oxidant-antioxidant balance. Exercise training does not only improve the circulatory functions, but it also initiates an anti-inflammatory process to defend against the angiotensin-II-induced renal injury.

show abstract

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Cited by 23 publications

References 34 publications

The effects of aerobic exercise on eGFR, blood pressure and VO2peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis

The effects of aerobic exercise on eGFR, blood pressure and VO2peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

Regular swimming exercise performed either before or after the induction of renovascular hypertension alleviates oxidative renal injury in rats

Contact Info

Product

Resources

About