Theranostic Mesoporous Silica Nanoparticles Biodegrade after Pro-Survival Drug Delivery and Ultrasound/Magnetic Resonance Imaging of Stem Cells

Kempen, Paul; Greasley, Sarah L.; Parker, Kelly; Campbell, Jos L.; Chang, Huan-Yu; Jones, Julian R.; Sinclair, Robert; Gambhir, Sanjiv S.; Jokerst, Jesse V.

doi:10.7150/thno.11389

Cited by 178 publications

(148 citation statements)

References 62 publications

(71 reference statements)

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“…These biodegradation byproducts are non-toxic to different cell lines [85]. More recently, it was reported that theranostic MSNs biodegraded after drug delivery and ultrasound/magnetic resonance imaging of stem cells [86]. It is also worth noting that a different line of effort has begun that involves introducing biodegradability into MSN.…”

Section: Biocompatibility Safety and Biodegradabilitymentioning

confidence: 99%

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

Mekaru

Lü

Tamanoi

2015

Advanced Drug Delivery Reviews

230

145

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Nanoparticles that respond to internal and external stimuli to carry out controlled release of anticancer drugs have been developed. In this review, we focus on the development of mesoporous silica based nanoparticles, as this type of materials provides a relatively stable material that is amenable to various chemical modifications. We first provide an overview of various designs employed to construct MSN-based controlled release systems. These systems respond to internal stimuli such as pH, redox state and the presence of biomolecules as well as to external stimuli such as light and magnetic field. They are at a different stage of development; depending on the system, their operation has been demonstrated in aqueous solution, in cancer cells or in animal models. Efforts to develop MSNs with multi-functionality will be discussed. Safety and biodegradation of MSNs, issues that need to be overcome for clinical development of MSNs, will be discussed. Advances in the synthesis of mechanized theranostic nanoparticles open up the possibility to start envisioning future needs for medical equipment.

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Section: Biocompatibility Safety and Biodegradabilitymentioning

confidence: 99%

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

Mekaru

Lü

Tamanoi

2015

Advanced Drug Delivery Reviews

230

145

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“…Moreover, the nanoparticles elicit low immune response, determined by low production of the most common inflammatory cytokines, known as interleukin-6, interleukin-12, and 1β in vivo [24]. Another experiment done in vivo, in nude mice with labelled silica nanoparticles and assessed by ultrasound, showed low cytotoxicity; in three days, the silica started to degrade from inside out in an in vitro test [25]. Functionalization of silica nanoparticles with 3-Aminopropyltriethoxysilane (APTES) for surface amination, using the silanol groups as anchoring sites, have been reported by various groups, followed by further grafting with anti-cancer drugs or tumor-directing agents [26,27].…”

Section: Introductionmentioning

confidence: 99%

Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles

et al. 2018

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Recently, flufenamic acid (FFA) was discovered among fenamates as a free radical scavenger and gap junction blocker; however, its effects have only been studied in cancer cells. Normal cells in the surroundings of a tumor also respond to radiation, although they are not hit by it directly. This phenomenon is known as the bystander effect, where response molecules pass from tumor cells to normal ones, through communication channels called gap junctions. The use of the enhanced permeability and retention effect, through which drug-loaded nanoparticles smaller than 200 nm may accumulate around a tumor, can prevent the local side effect upon controlled release of the drug. The present work, aimed at functionalizing MCM-41 (Mobil Composition of Matter No. 41) silica nanoparticles with FFA and determining its biocompatibility with human fibroblasts MRC-5 (Medical Research Council cell strain 5). MCM-41, was synthesized and characterized structurally and chemically, with multiple techniques. The biocompatibility assay was performed by Live/Dead technique, with calcein and propidium–iodide. MRC-5 cells were treated with FFA-grafted MCM-41 for 48 h, and 98% of cells remained viable, without signs of necrosis or morphological changes. The results show the feasibility of MCM-41 functionalization with FFA, and its potential protection of normal cells, in comparison to the role of FFA in cancerous ones.

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“…Echocardiography can be used to avoid implantation into fibrotic tissue, but cellular imaging for surgical guidance is limited by the lack of available contrast agents. Paul J Kempen et al [26] proposed an MSN that solves both these major limitations through a combined therapeutic and diagnostic-"theranostic"-approach. Silica-based nanoparticles offer contrast for ultrasound imaging [26].…”

Section: Introductionmentioning

confidence: 99%

“…Paul J Kempen et al [26] proposed an MSN that solves both these major limitations through a combined therapeutic and diagnostic-"theranostic"-approach. Silica-based nanoparticles offer contrast for ultrasound imaging [26]. MSNs are biocompatible, preferentially accumulate in tumors and effectively deliver drugs to tumors and suppress tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

Jadhav¹

2015

JNMR

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Chemistry, synthesis and functionalization of MSNsWith an abundant availability of various types of surfactants and the development of a deep understanding of sol-gel chemistry, MSNs with different structures have been developed. The size, morphology, pore size and pore structure of MSNs can be rationally designed and the synthesis process can be freely AbstractNanotechnology is a fast-growing area, involving the fabrication and use of nano-sized materials and devices. Nanocomposite materials play a number of important roles in modern science and technology, including pharmaceutical science. Mesoporous materials in particular have a large number of applications. In the past decade, mesoporous silica nanoparticles (MSNs) attracted attention increasingly for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs have significant advantages as drug delivery systems (DDSs) compared with traditional drug nanocarriers. Inorganic mesoporous materials are being used increasingly in pharmaceutical materials research to enhance the dissolution and permeation behavior of drugs that are poorly soluble in water. The benefits of using mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. In this work, we review recent progress in the synthesis and surface functionalization of MSNs for drug delivery applications.

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Theranostic Mesoporous Silica Nanoparticles Biodegrade after Pro-Survival Drug Delivery and Ultrasound/Magnetic Resonance Imaging of Stem Cells

Cited by 178 publications

References 62 publications

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy

Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

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