Theranostic efficiency of biosurfactants against COVID-19 and similar viruses - A review

Sarangi, Manoj Kumar; Padhi, Sasmita; Patel, L.D.; Rath, Goutam; Nanda, Sitansu Sekhar; Yi, Dong Kee

doi:10.1016/j.jddst.2022.103764

Cited by 7 publications

(6 citation statements)

References 109 publications

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“…They may disrupt viral envelopes, rendering the viruses non-infectious. Biosurfactants could also interfere with viral entry into host cells or disrupt viral particles, inhibiting their infection ability (Sarangi et al,2022;Raza et al, 2023).…”

Section: Antiviral Propertiesmentioning

confidence: 99%

Biosurfactants: Moving Towards Healthcare Applications

Purohit,

Dubey,

Rath

et al. 2024

IJALSR

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Biosurfactants, fascinating molecules originating from microbial sources, have captivated researchers' imaginations for their escalating potential across a spectrum of healthcare applications. This comprehensive review explores the multifaceted world of biosurfactants, elucidating their diverse nature and exceptional physicochemical properties, propelling them toward becoming game-changers in healthcare. It represents a captivating array of compounds, boasting structural diversity encompassing glycolipids, lipopeptides, fatty acids, phospholipids, and more. These microbial marvels, formed at the intersection of hydrophilicity and hydrophobicity, offer adaptability and utility that extend across various applications. They wield the power to reduce surface and interfacial tension, making them adept at emulsifying immiscible substances. Biosurfactants serve as formidable antimicrobial agents combating drug-resistant bacteria and emerging viral threats. In the realm of wound care and tissue regeneration, biosurfactants shine. They promote wound healing and tissue repair through enhanced cell migration and regeneration opening new vistas for healthcare professionals. Biosurfactants have found their place in pharmaceutical formulations, elevating drug solubility and stability. These molecules significantly improve drug delivery systems, potentially amplifying their therapeutic efficacy. In cosmetics and personal care products, biosurfactants contribute to their emulsifying prowess, enhancing product texture and quality. They are also making their mark in the food industry, improving the solubility of bioactive compounds, and expanding the horizons of functional food additives. Biosurfactants are integral to diagnostic assays, offering improved stability and sensitivity. While biosurfactants hold immense promise, challenges include sustainability and environmental considerations. However, the burgeoning field of biosurfactants in healthcare beckons further research and development.

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Section: Antiviral Propertiesmentioning

confidence: 99%

Biosurfactants: Moving Towards Healthcare Applications

Purohit,

Dubey,

Rath

et al. 2024

IJALSR

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“…This is achieved through the creation of channels for ions. This process intensifies at higher surfactant concentrations, leading to disturbances in the membrane system [ 98 ]. Under specific conditions, biosurfactants have showcased their potential in inactivating a range of viruses, including herpes viruses, retroviruses, and other enveloped RNA or DNA viruses.…”

Section: Application Of Biosurfactants In Medical Sciencesmentioning

confidence: 99%

Application of Biosurfactants in Medical Sciences

Wang,

An,

Cao

et al. 2024

Molecules

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Biosurfactants derived from microorganisms have attracted widespread attention in scientific research due to their unique surface activity, low toxicity, biodegradability, antibacterial properties, and stability under extreme conditions. Biosurfactants are widely used in many fields, such as medicine, agriculture, and environmental protection. Therefore, this review aims to comprehensively review and analyze the various applications of biosurfactants in the medical field. The central roles of biosurfactants in crucial medical areas are explored, like drug delivery, induction of tumor cell differentiation or death, treating bacterial and viral effects, healing wounds, and immune regulation. Moreover, a new outlook is introduced on optimizing the capabilities of biosurfactants through modification and gene recombination for better use in medicine. The current research challenges and future research directions are described, aiming to provide valuable insights for continuous study of biosurfactants in medicine.

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“…With Covid-19 infection, a healthy immune system entirely eradicates the virus without the patient displaying any symptoms. By inducing or activating immune cells such as macrophage, neutrophils, B cells and T cells, which deals with the production and memory storage of viral specific antibodies for recurrent infections, an effective adaptive immune response can be produced [120] . For example, inducing T cells facilitate the differentiation B cells into memory cells and plasma cells producing viral specific antibodies for recurrent infections [121] .…”

Section: Biosurfactants: Approach Toward Prevention and Management Of...mentioning

confidence: 99%

“…Some of the studies reported earlier revealed role of BSs along with bioactive peptides for inactivation of encapsulated viruses. For example, the biopeptide cyclosporine A, produced by the fungus Tolypocladium inflatum , apparently impeded the influenza viruses’ life cycle by preventing or delaying viral assembly following the synthesis of protein [120] . It was formerly thought that focusing on viral life cycle may be helpful in addressing antiviral drug resistance thereby liming the disease propagation.…”

Section: Biosurfactants: Approach Toward Prevention and Management Of...mentioning

confidence: 99%