Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

Kawasaki, Riku; Kondo, Kosuke; Miura, Risako; Yamana, Keita; Isozaki, Hinata; Shimada, Risako; Kawamura, Shogo; Hirano, Hidetoshi; Nishimura, Tomoki; Tarutani, Naoki; Katagiri, Kiyofumi; Stubelius, Alexandra; Sawada, Shin–ichi; Sasaki, Yoshihiro; Akiyoshi, Kazunari; Ikeda, Atsushi

doi:10.3390/ijms23094686

Cited by 11 publications

(10 citation statements)

References 36 publications

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“…[28][29][30][31][32][33][34][35][36][37] In the present study, we used pullulan (Pul), conventional water-solubilizer, as a control host molecule. [28,31,33,[36][37] The solubility of polyphenols was confirmed by measuring the UV-Vis absorption spectra of resulting dispersions (Figure 2a). All biopolymers were able to form water-dispersible inclusion complexes with Res (Figure 2a, solid line) and Cur (Figure 2a, dashed line).…”

Section: Preparation Of a Water Dispersible Complex Of Polypeptides A...mentioning

confidence: 99%

Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Kawasaki

Kawamura

Kodama

et al. 2023

Macromolecular Bioscience

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The prevalence of allergic disorders has increased worldwide in recent decades. Polyphenols, including resveratrol and curcumin, are posited to have potential as therapeutic agents for allergy; however, their use has been limited by poor water solubility. Accordingly, a highly concentrated, water dispersible, supramolecular complexes of polyphenols with polypeptides (poly‐L‐lysine, poly‐γ‐glutamic acid) and gelatin using high‐speed vibration milling are developed. The complex exhibits resistance to photobleaching and thermal radiation. Treatment of a rat basophilic leukemia cell line (RBL‐2H3) with polypeptide complexes containing resveratrol is suppressed allergic responses in vitro. Moreover, aerosolized administration of polypeptide complexes demonstrates excellent bioavailability and inhibition of immediate hypersensitivity reactions in ear tissue in vivo. Furthermore, the method avoids the use of organic solvent and therefore reduces undesirable biological responses.

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Section: Preparation Of a Water Dispersible Complex Of Polypeptides A...mentioning

confidence: 99%

Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Kawasaki

Kawamura

Kodama

et al. 2023

Macromolecular Bioscience

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“…(3) The third group is similar to the second group, except that they respond to external stimuli such as a magnetic field or IR. For example, nanoshells and nanorods with maximum infrared absorption and efficient light conversion into thermal energy are used in thermal ablation therapy. − …”

Section: Introductionmentioning

confidence: 99%

Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis

Hosseini

Mohammadnejad

Najafi-Taher

et al. 2023

ACS Appl. Bio Mater.

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Cancer diagnosis and treatment are the most critical challenges in modern medicine. Conventional cancer treatments no longer meet the needs of the health field due to the high rate of mutations and epigenetic factors that have caused drug resistance in tumor cells. Hence, the search for unique methods and factors is quickly expanding. The development of nanotechnology in medicine and the search for a system to integrate treatment and diagnosis to achieve an effective approach to overcome the known limitations of conventional treatment methods have led to the emergence of theranostic nanoparticles and nanosystems based on these nanoparticles. An influential group of these nanoparticles is carbon-based theranostic nanoparticles. These nanoparticles have received significant attention due to their unique properties, such as electrical conductivity, high strength, excellent surface chemistry, and wide range of structural diversity (graphene, nanodiamond, carbon quantum dots, fullerenes, carbon nanotubes, and carbon nanohorns). These nanoparticles were widely used in various fields, such as tissue engineering, drug delivery, imaging, and biosensors. In this review, we discuss in detail the recent features and advances in carbon-based theranostic nanoparticles and the advanced and diverse strategies used to treat diseases with these nanoparticles.

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“…The diagnostic method, bioimaging, is connected with the penetration of drugs and diagnostic agents into tissues and cells and the sensitivity of detection. Bioimaging is controlled by biodegradability, biocompatibility, specificity, and applicability for carbon nanotubes [68][69][70][71][72][73][74][75][76][77][78][79][80][81], graphene [82][83][84][85][86][87][88][89][90][91][92][93][94], fullerenes [95], and dots [96].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Carbon Nanotubes, Graphene, Fullerenes, and Dots

Kharlamova

Kramberger

2023

Nanomaterials

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The cytotoxicity of carbon nanomaterials is a very important issue for microorganisms, animals, and humans. Here, we discuss the issues of cytotoxicity of carbon nanomaterials, carbon nanotubes, graphene, fullerene, and dots. Cytotoxicity issues, such as cell viability and drug release, are considered. The main part of the review is dedicated to important cell viability issues. They are presented for A549 human melanoma, E. coli, osteosarcoma, U2-OS, SAOS-2, MG63, U87, and U118 cell lines. Then, important drug release issues are discussed. Bioimaging results are shown here to illustrate the use of carbon derivatives as markers in any type of imaging used in vivo/in vitro. Finally, perspectives of the field are presented. The important issue is single-cell viability. It can allow a correlation of the functionality of organelles of single cells with the development of cancer. Such organelles are mitochondria, nuclei, vacuoles, and reticulum. It allows for finding biochemical evidence of cancer prevention in single cells. The development of investigation methods for single-cell level detection of viability stimulates the cytotoxicity investigative field. The development of single-cell microscopy is needed to improve the resolution and accuracy of investigations. The importance of cytotoxicity is drug release. It is important to control the amount of drug that is released. This is performed with pH, temperature, and electric stimulation. Further development of drug loading and bioimaging is important to decrease the cytotoxicity of carbon nanomaterials. We hope that this review is useful for researchers from all disciplines across the world.

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Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

Cited by 11 publications

References 36 publications

Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Development of a Water‐Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy

Multifunctional Carbon-Based Nanoparticles: Theranostic Applications in Cancer Therapy and Diagnosis

Cytotoxicity of Carbon Nanotubes, Graphene, Fullerenes, and Dots

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