Theragnostic strategies harnessing the self-renewal pathways of stem-like cells in the acute myeloid leukemia

Bhattacharjee, Rahul; Ghosh, Sharad; Nath, Arijit; Basu, Asmita; Biswas, Ojaswi; Patil, Chandragauda R; Kundu, Chanakya Nath

doi:10.1016/j.critrevonc.2022.103753

Cited by 7 publications

(7 citation statements)

References 140 publications

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“…AML is listed among the most common hematologic malignancies [29,30]. Despite progress in the treatment of AML, it remains difficult to treat and cure, and the 5-year overall survival rate, especially in sufferers which age is over 60 years, is still very low [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Enhanced MCM5 Level Predicts Bad Prognosis in Acute Myeloid Leukemia

Wang

Han

2022

Mol Biotechnol

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Acute myeloid leukemia (AML) is a fatal heterogeneous hematologic malignancy. There is an urgent need to identify potential biomarkers to better classify sufferers with bad outcomes that might need more advanced treatment. The objective of this study was to investigate prognostic indicators that predict the outcome of sufferers with AML. The datasets of AML sufferers including mRNA sequencing data and clinical information were acquired from GEO datasets (GSE38865) and TCGA datasets. Kaplan–Meier curves and Cox regression analysis to screen genes correlated to survival. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses biological process analysis were utilized in verifying the function of various genes. Sufferers with elevated MCM5 level exhibited a worse prognosis, according to the survival analysis. It was indicated through multivariate and univariate analysis that MCM5 level was an independent adverse prognostic element for over survival in AML sufferers based on GEO and TCGA datasets. Meanwhile, MCM5 level in AML samples was higher than in normal samples. Additionally, it was indicated through PPI network and functional enrichment analyses that through accelerating cell cycle and DNA replication, MCM5 promoted AML progression. In conclusions, MCM5 level was an independent poor prognostic element in AML sufferers based on GEO and TCGA datasets. This is the first time that MCM5 is reported to be a biomarker of poor prognosis in AML.

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Section: Discussionmentioning

confidence: 99%

Enhanced MCM5 Level Predicts Bad Prognosis in Acute Myeloid Leukemia

Wang

Han

2022

Mol Biotechnol

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“…Precision drug delivery has been a problem in the tumor microenvironment for quite some time, and the application of zein NPs for targeted drug delivery could mitigate the problem (Figure ). − Herein we have discussed the clinical significance of zein NPs for drug delivery of anticancer compounds, summarized in Table .…”

Section: Zein Nanosystems For Drug Delivery In Anticancer Therapymentioning

confidence: 99%

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Preetam,

Duhita Mondal,

Mukerjee

et al. 2024

ACS Biomater. Sci. Eng.

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Various nanomaterials have recently become fascinating tools in cancer diagnostic applications because of their multifunctional and inherent molecular characteristics that support efficient diagnosis and image-guided therapy. Zein nanoparticles are a protein derived from maize. It belongs to the class of prolamins possessing a spherical structure with conformational properties similar to those of conventional globular proteins like ribonuclease and insulin. Zein nanoparticles have gained massive interest over the past couple of years owing to their natural hydrophilicity, ease of functionalization, biodegradability, and biocompatibility, thereby improving oral bioavailability, nanoparticle targeting, and prolonged drug administration. Thus, zein nanoparticles are becoming a promising candidate for precision cancer drug delivery. This review highlights the clinical significance of applying zein nanosystems for cancer theragnostic� moreover, the role of zein nanosystems for cancer drug delivery, anticancer agents, and gene therapy. Finally, the difficulties and potential uses of these NPs in cancer treatment and detection are discussed. This review will pave the way for researchers to develop theranostic strategies for precision medicine utilizing zein nanosystems.

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“…It is characterized by an intense clonal proliferation of tumoral myeloid stem cells in the bone marrow, due to the onset of malignant alteration of hematopoietic stem cells that go through succeeding genetic changes, finally giving rise to an overt malignancy. Biological features of AML are enormously composite with relevant genetic, epigenetic, and phenotypic variants, which differ from each other by molecular and genomic modifications involving genes that are implicated in cell growth, differentiation and survival [ 79 , 80 ].…”

Section: Aqps and Hematological Malignanciesmentioning

confidence: 99%

Critical Role of Aquaporins in Cancer: Focus on Hematological Malignancies

Allegra

Cicero

Mirabile

et al. 2022

Cancers

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Aquaporins are transmembrane molecules regulating the transfer of water and other compounds such as ions, glycerol, urea, and hydrogen peroxide. Their alteration has been reported in several conditions such as cancer. Tumor progression might be enhanced by aquaporins in modifying tumor angiogenesis, cell volume adaptation, proteases activity, cell–matrix adhesions, actin cytoskeleton, epithelial–mesenchymal transitions, and acting on several signaling pathways facilitating cancer progression. Close connections have also been identified between the aquaporins and hematological malignancies. However, it is difficult to identify a unique action exerted by aquaporins in different hemopathies, and each aquaporin has specific effects that vary according to the class of aquaporin examined and to the different neoplastic cells. However, the expression of aquaporins is altered in cell cultures and in patients with acute and chronic myeloid leukemia, in lymphoproliferative diseases and in multiple myeloma, and the different expression of aquaporins seems to be able to influence the efficacy of treatment and could have a prognostic significance, as greater expression of aquaporins is correlated to improved overall survival in leukemia patients. Finally, we assessed the possibility that modifying the aquaporin expression using aquaporin-targeting regulators, specific monoclonal antibodies, and even aquaporin gene transfer could represent an effective therapy of hematological malignancies.

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Theragnostic strategies harnessing the self-renewal pathways of stem-like cells in the acute myeloid leukemia

Cited by 7 publications

References 140 publications

Enhanced MCM5 Level Predicts Bad Prognosis in Acute Myeloid Leukemia

Enhanced MCM5 Level Predicts Bad Prognosis in Acute Myeloid Leukemia

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Critical Role of Aquaporins in Cancer: Focus on Hematological Malignancies

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