Theory of the center-of-mass diffusion and viscosity of microstructured and variable sequence copolymer liquids

Shi, Guang; Schweizer, Kenneth S.

doi:10.1039/d3sm01193c

Cited by 5 publications

(2 citation statements)

References 82 publications

(178 reference statements)

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“…We believe that the molecular insights provided in this work will aid in further theoretical developments 78 as well as computational and experimental investigations of diverse sequence features in dictating condensate dynamics, leading to a comprehensive molecular language for the material properties of biomolecular condensates.…”

Section: Discussionmentioning

confidence: 92%

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations

Devarajan

Wang

Nikoubashman

et al. 2023

Preprint

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Material properties of phase-separated biomolecular assemblies, enriched with disordered proteins, dictate their ability to participate in many cellular functions. Despite the significant effort dedicated to understanding how the sequence of the disordered protein drives its phase separation to form condensates, little is known about the sequence determinants of condensate material properties. Here, we decipher these relationships for charged disordered proteins using model sequences comprised of glutamic acid and lysine residues as well as naturally occurring sequences of LAF1's RGG domain and DDX4's N-terminal domain. We do so by delineating how the arrangement of oppositely charged residues within these sequences influences the dynamical, rheological, and interfacial properties of the condensed phase. Interestingly, we find that the material properties of both the model and natural proteins respond similarly to the segregation of charges, despite their very different sequence compositions. Condensates of the highly charge-segregated sequences exhibit slower dynamics than the uniformly charge-patterned sequences, because of their comparatively long-lived molecular contacts between oppositely charged residues. Surprisingly, the molecular interactions within the condensate are highly similar to those within a single-chain for all sequences. Consequently, the condensate material properties of charged disordered proteins are strongly correlated with their dense-phase contact dynamics and their single-chain structural properties. Our findings demonstrate the potential to harness the sequence characteristics of disordered proteins for engineering the material properties of functional condensates, with insights from the dilute-phase properties.

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Section: Discussionmentioning

confidence: 92%

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations

Devarajan

Wang

Nikoubashman

et al. 2023

Preprint

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“…The diffusion theory suggests that the continuous thermal movement of key substances between materials can cause mutual diffusion, leading to the formation of interwoven and firm bonds between materials. The strength of this bond increases to its maximum value over time [ 36 ]. Introducing diffusion theory into this study can provide evidence for the interaction between population and welfare systems and construct a theoretical framework with explanatory significance, integrating population and social welfare into the framework of regional sustainable development.…”

Section: Introductionmentioning

confidence: 99%

Regional population and social welfare from the perspective of sustainability: Evaluation indicator, level measurement, and interaction mechanism

Wang,

Li,

et al. 2024

PLoS ONE

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Key to regional sustainable development are the development and interplay of population dynamics and social welfare, each playing a significant role. As a representative region with demographic characteristics such as negative population growth and large labor outflow, the development and interaction between population and social welfare in Nanchong deserve in-depth exploration. This article takes the development of population and social welfare in Nanchong as the research object, and constructs an evaluation indicator system of population and social welfare through research backtracking, and uses entropy method and coupling coordination model to measure the development level and interactive effect of population and social welfare in Nanchong from 2010 to 2021. The research results show that: Firstly, the comprehensive evaluation results of population in Nanchong shows a linear upward trend, which indicates the stable positive effect of population structure and distribution, the gradual improvement effect of population quality effectively compensate for the weakening effect of population quantity, thus achieving the positive development of population. Secondly, the comprehensive evaluation results of social welfare in Nanchong shows an exponential upward trend, which indicates the social welfare has maintained a rapid growth momentum in various dimensions and the long-term positive effects have completely absorbed the negative effects, thus achieving the positive development of social welfare. Thirdly, during the sample period, the population and social welfare in Nanchong consistently maintained a high level of interaction strength, with factors diffusing and integrating. On this basis, the diffusion theory is used as an empirical reference to construct three interactive mechanisms between the population and social welfare in Nanchong and the implications are inferred from the empirical results.

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Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations

Sundaravadivelu Devarajan,

Wang,

Szała-Mendyk

et al. 2024

Nat Commun

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Material properties of phase-separated biomolecular condensates, enriched with disordered proteins, dictate many cellular functions. Contrary to the progress made in understanding the sequence-dependent phase separation of proteins, little is known about the sequence determinants of condensate material properties. Using the hydropathy scale and Martini models, we computationally decipher these relationships for charge-rich disordered protein condensates. Our computations yield dynamical, rheological, and interfacial properties of condensates that are quantitatively comparable with experimentally characterized condensates. Interestingly, we find that the material properties of model and natural proteins respond similarly to charge segregation, despite different sequence compositions. Molecular interactions within the condensates closely resemble those within the single-chain ensembles. Consequently, the material properties strongly correlate with molecular contact dynamics and single-chain structural properties. We demonstrate the potential to harness the sequence characteristics of disordered proteins for predicting and engineering the material properties of functional condensates, with insights from the dilute phase properties.

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Theory of the center-of-mass diffusion and viscosity of microstructured and variable sequence copolymer liquids

Abstract: We present a microscopic dynamical theory for the slowing down of copolymer center-of-mass diffusion in the strongly segregated homogeneous microemulsion state. Our findings are pertinent to synthetic copolymers and biomolecular condensates.

Cited by 5 publications

References 82 publications

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations

Regional population and social welfare from the perspective of sustainability: Evaluation indicator, level measurement, and interaction mechanism

Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations

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