Theory of Ternary Fluids under Centrifugal Fields

Stemplinger, Simon; Prévost, Sylvain; Zemb, Thomas; Horinek, Dominik; Dufrêche, Jean‐François

doi:10.1021/acs.jpcb.1c05875

Cited by 7 publications

(7 citation statements)

References 53 publications

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“…In combination with the DLS curves (cf. Figure S2), one can see that, for this kind of solubilization, a defined pre-structuring is hardly important but rather fluctuations of the global network [33].…”

Section: Phase Diagrams and Curcumin Solubilitymentioning

confidence: 96%

Improvement of the Solubilization and Extraction of Curcumin in an Edible Ternary Solvent Mixture

et al. 2021

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A water-free, ternary solvent mixture consisting of a natural deep eutectic solvent (NADES), ethanol, and triacetin was investigated concerning its ability to dissolve and extract curcumin from Curcuma longa L. To this purpose, 11 NADES based on choline chloride, acetylcholine, and proline were screened using UV–vis measurements. A ternary phase diagram with a particularly promising NADES, based on choline chloride and levulinic acid was recorded and the solubility domains of the monophasic region were examined and correlated with the system’s structuring via light scattering experiments. At the optimum composition, close to the critical point, the solubility of curcumin could be enhanced by a factor of >1.5 with respect to acetone. In extraction experiments, conducted at the points of highest solubility and evaluated via HPLC, a total yield of ~84% curcuminoids per rhizome could be reached. Through multiple extraction cycles, reusing the extraction solvent, an enrichment of curcuminoids could be achieved while altering the solution. When counteracting the solvent change, even higher concentrated extracts can be obtained.

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Section: Phase Diagrams and Curcumin Solubilitymentioning

confidence: 96%

Improvement of the Solubilization and Extraction of Curcumin in an Edible Ternary Solvent Mixture

et al. 2021

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“…An approach conceptually similar to sedimentation path theory that also relies on local equilibrium conditions has been recently used to study sedimentation profiles of molecular systems in centrifugal fields [58]. Even though the gravitational field is not constant under centrifugation, the sedimentation paths are still lines in the space of chemical potentials.…”

Section: Discussionmentioning

confidence: 99%

Sedimentation of colloidal plate-sphere mixtures and inference of particle characteristics from stacking sequences

Eckert

Schmidt

Heras

2022

Phys. Rev. Research

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We investigate theoretically the effect of gravity on a plate-sphere colloidal mixture by means of an Onsager-like density functional to describe the bulk, and sedimentation path theory to incorporate gravity. We calculate the stacking diagram of the mixture for two sets of buoyant masses and different values of the sample height. Several stacking sequences appear due to the intricate interplay between gravity, the sample height, and bulk phase separation. These include the experimentally observed floating nematic sequence, which consists of a nematic layer sandwiched between two isotropic layers. The values of the thicknesses of the layers in a complex stacking sequence can be used to obtain microscopic information of the mixture. Using the thicknesses of the layers in the floating nematic sequence we are able to infer the values of the buoyant masses from the colloidal concentrations and vice versa. We also predict new phenomena that can be experimentally tested, such as a nontrivial evolution of the stacking sequence by increasing the sample height in which new layers appear either at the top or at the bottom of the sample.

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“…The theoretical prediction of the system follows the procedure of our recent work, 19 where also further details of the derivation are given. The free energy of the system is a functional of the particle densities {𝜌 !…”

Section: Theorymentioning

confidence: 99%

“…The experimental observations are rationalized with the help our recently developed centrifugation map (CMap) theory. 19…”

Section: Introductionmentioning

confidence: 99%

Two types of liquid phase separation induced by soft centrifugation in aqueous ethyl acetate using ethanol as co-solvent

Coelfen

Rosenberg

Haffke

et al. 2022

Preprint

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Water-ethyl acetate-ethanol is widely used as “green” extractant system. We show that two different types of phase separation can be induced upon centrifugation in this ternary system using ethanol as a co-solvent of water and ethyl acetate (EA): centrifuge-induced criticality and centrifuge-induced emulsification. The expected composition profiles of samples after centrifugation can be represented by bent lines in a ternary phase diagram when gravitational energy is added to the free energy of mixing. The experimental equilibrium composition profiles behave qualitatively as expected and can be predicted using a phenomenological theory of mixing. The concentration gradients are small except near the critical point, as expected for small molecules. Nevertheless, they are usable when accompanied by temperature cycles. These findings open new possibilities of centrifugal separation, even if control is delicate during temperature cycles. These schemes are accessible even at relatively low centrifugation speed for molecules that float and sediment with apparent molar masses several hundred times larger than the molecular mass.

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Theory of Ternary Fluids under Centrifugal Fields

Cited by 7 publications

References 53 publications

Improvement of the Solubilization and Extraction of Curcumin in an Edible Ternary Solvent Mixture

Improvement of the Solubilization and Extraction of Curcumin in an Edible Ternary Solvent Mixture

Sedimentation of colloidal plate-sphere mixtures and inference of particle characteristics from stacking sequences

Two types of liquid phase separation induced by soft centrifugation in aqueous ethyl acetate using ethanol as co-solvent

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