Theory of Spatial Patterns of Intracellular Organelles

Dinh, Anh-Tuan; Pangarkar, Chinmay; Theofanous, T.G.; Mitragotri, Samir

doi:10.1529/biophysj.106.082875

Cited by 22 publications

(19 citation statements)

References 15 publications

(27 reference statements)

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“…A more recent approach analyzes the entire distribution of organelles within cells. [21][22][23] The theory combines assumptions about intracellular transport mechanisms with known details of the cell's internal structural environment, and makes predictions that are in agreement with observed distributions of mitochondria, endosomes, melanosomes and peroxisomes in various cell types. This new approach is useful because it indirectly validates presumed transport mechanisms and it helps identify the predominant mechanisms.…”

Section: Introductionmentioning

confidence: 78%

Cell-assisted assembly of colloidal crystallites

et al. 2007

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Many cells ingest foreign particles through a process known as phagocytosis. It now turns out that some cell types organize phagocytosed microparticles into crystalline arrays. Much like the classic crystallization of colloidal particles in a thermal bath, crystallization within the cell is driven by the spatial confinement of mutually repelling particles, in this case by the cell membrane. Cytoskeleton-driven motions exert a randomizing force, similar to but stronger than thermal forces; these motions anneal defects and purify the colloidal crystals within the cells. Bidisperse mixtures of microspheres phase separate within the cell, with the larger particles crystallizing around the nucleus and the smaller particles crystallizing around the perimeter of the large particle array. Mitochondria also participate in this kind of size segregation, which appears to be driven by membrane tension and curvature minimization. Beyond the curiosity of the phenomenon itself, cell-assisted colloidal assembly may prove useful as a new tool to study a variety of biophysical processes including cytoskeletal rearrangements, organelle–membrane interactions, the in vivo mechanics of microtubules, the cooperativity of molecular motors and intracellular traffic jams on cytoskeletal filaments

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Section: Introductionmentioning

confidence: 78%

Cell-assisted assembly of colloidal crystallites

et al. 2007

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“…These limitations provide further motivation to derive a mathematical model in order to obtain an accurate representation which can be used to compare and validate experimental data as well as to make hypothetical predictions testable in laboratories. Using data obtained from in-vitro assays and through the use of ImageJ, we plot a sample of velocities of individually tracked endosomes as shown in [11,15,31,32,54]. Ashwin et al, [2] use an asymmetric simple exclusion process to model the motion of dynein along microtubles, both dynein that is carried towards the positive-end by kinesin and dynein that moves towards the negative-end.…”

Section: Methodsmentioning

confidence: 99%

From the Cell Membrane to the Nucleus: Unearthing Transport Mechanisms for Dynein

et al. 2012

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Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-MarieTooth disease in humans, spinal muscular atrophy and severe intellectual disabilities in humans.In mouse models neurodegeneration is observed. We sought to develop a novel model which could incorporate the effect of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments.

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“…Indeed, the MTs are known to be used as preferential ways of motion by macro molecules (e.g. adenoviruses [16]) and intracellular organelles (e.g. endocytic vesicles [16]).…”

Section: Active Transport Along the Microtubulesmentioning

confidence: 99%

“…adenoviruses [16]) and intracellular organelles (e.g. endocytic vesicles [16]). The size of these entities (the adenoviruses are 90nm in diameter) limits considerably their diffusion speed in the cytoplasm; for this reason they must resort to active transport along the MTs in order to reach their target location.…”

Section: Active Transport Along the Microtubulesmentioning

confidence: 99%

A spatial model of cellular molecular trafficking including active transport along microtubules

Cangiani

Natalini

2010

Journal of Theoretical Biology

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To cite this version:A. Cangiani, R. Natalini. A spatial model of cellular molecular trafficking including active transport along microtubules. Journal of Theoretical Biology, Elsevier, 2010, 267 (4) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A SPATIAL MODEL OF CELLULAR MOLECULAR TRAFFICKING INCLUDING ACTIVE TRANSPORT ALONG MICROTUBULESA. CANGIANI * , R. NATALINI † Abstract. We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on Discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.

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Theory of Spatial Patterns of Intracellular Organelles

Cited by 22 publications

References 15 publications

Cell-assisted assembly of colloidal crystallites

Cell-assisted assembly of colloidal crystallites

From the Cell Membrane to the Nucleus: Unearthing Transport Mechanisms for Dynein

A spatial model of cellular molecular trafficking including active transport along microtubules

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