“…How to tackle this problem ideally has been an open question for decades [43][44][45][46][47][48]. The active convolved illumination (ACI) technique has recently been proposed theoretically as a ubiquitous noise and distortion mitigation scheme to improve the image signal-to-noise (SNR) ratio by systematically manipulating the image spectrum depending on the underlying stochastic behavior [2,32,37,[39][40][41]. Popular techniques to improve image resolution or SNR are structured illumination microscopy (SIM) [3,[49][50][51][52][53], stimulated emission depletion (STED) microscopy [49,54,55], stochastic optical reconstruction microscopy/photoactivated localization microscopy (STORM/PALM) [49,56,57], and computational methods [43][44][45][46][47][48][58][59][60] including machine learning [42,61,62].…”