With the development of digitalization and globalization, the power discourse system faced by the whole world has undergone tremendous changes, and post-structuralism as a subversion of the meaning of traditional political discourse has become more and more reflected. Due to the imperfection of post-structuralist theory, the role of its theoretical framework is often questioned. Therefore, starting from the progressive significance of post-structuralism to structuralism, it is undoubtedly a critical research topic to rethink the post-structuralist framework's role in political analysis. This paper starts with the relationship between structuralism and post-structuralism and understands some of the progressive significance of post-structuralism in political research in the new era. Secondly, starting from Saussure's semiotics, this paper explores the role of signifier and signified in the derived meaning chain and on this basis, plays the role of deconstruction metaphysics and traditional ontology in the field of political analysis. Thirdly, the theoretical convergence of post-structuralism and Marxism is also a critical research path. Based on this, we can further determine the positive significance of Foucault's view of power in the effect of specific government governance. Through research, we can see that the post-structuralist framework is practical and enlightening in practice in the political field, and there is still much-unexplored potential behind it.