Theories, mechanisms, and models of alcoholic chronic pancreatitis

Pathobiology of Alcoholic Pancreatitis

“…This hypothesis is based on pancreatic tissue examination during alcoholic acute and chronic pancreatitis [56][57][58] . Early after the onset on pancreatitis symptoms there is evidence of postnecrotic changes such as pseudocytes; and morphology from surgical specimens showing predominant pancreatic lesions of focal necrosis and mild fibrosis.…”

The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis

“…However, the repetitive administration of the cerulein model has been limited for treatment time, severity, and human similarity. Therefore, we added alcohol consumption to the repetitive AP model to induced ACP because chronic excessive alcohol consumption is a major risk factor for developing chronic pancreatitis (16)(17)(18)(19). The 3 week challenge given to mice was sufficient to induce ACP, which was proven by fibrosis, inflammation, and acinar cell destruction in the pancreas (Fig.…”

Matrix metalloproteinases in pancreatitis: current insights

“…The change of resident fibroblasts/PSCs into myofibroblasts is caused by the damage to any one of these tissue compartments of the pancreas, which is associated with subsequent production and deposition of ECM, mainly consisting of collagen types I and III and fibronectin. 16 Alcoholism tops the list of different etiological factors causing pancreatitis (both AP and CP) in developed countries [17][18][19][20][21] but several studies suggest that alcohol per se may not cause pancreatitis. There is a marked heterogeneity in susceptibility to alcoholic CP (ACP) and clinically significant pancreatic disease occurs only in 10% of heavy alcohol users.…”

“…Therefore, it can be conclusive to say that alcohol is a cofactor in the development of ACP in susceptible humans. 19,[21][22][23] Therefore other genetic or environmental factors may contribute to the development of alcoholic pancreatitis.…”